Parahydrogen‐Induced Radio Amplification by Stimulated Emission of Radiation

Joalland, Baptiste, Nuwandi M. Ariyasingha, Sören Lehmkuhl, Thomas Theis, Stephan Appelt, and Eduard Y. Chekmenev. “Parahydrogen‐Induced Radio Amplification by Stimulated Emission of Radiation.” Angewandte Chemie International Edition 59, no. 22 (May 25, 2020): 8654–60.

https://doi.org/10.1002/anie.201916597

Radio amplification by stimulated emission of radiation (RASER) was recently discovered in a low-field NMR spectrometer incorporating a highly specialized radiofrequency resonator, where a high degree of proton-spin polarization was achieved by reversible parahydrogen exchange. RASER activity, which results from the coherent coupling between the nuclear spins and the inductive detector, can overcome the limits of frequency resolution in NMR. Here we show that this phenomenon is not limited to low magnetic fields or the use of resonators with high-quality factors. We use a commercial bench-top 1.4 T NMR spectrometer in conjunction with pairwise parahydrogen addition producing protonhyperpolarized molecules in the Earth s magnetic field (ALTADENA condition) or in a high magnetic field (PASADENA condition) to induce RASER without any radio-frequency excitation pulses. The results demonstrate that RASER activity can be observed on virtually any NMR spectrometer and measures most of the important NMR parameters with high precision.

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