Dr. Thorsten Maly

Dr. Thorsten Maly is a co-founder of Bridge12 Technologies, Inc. and currently serves as the Vice President Magnetic Resonance overseeing all research activities related to magnetic resonance spectroscopy. He has well over a decade of experience in the field of Electron Paramagnetic Resonance (EPR), solid-state NMR and Dynamic Nuclear Polarization (DNP) spectroscopy. His expertise includes development and application of pulsed-EPR experiments to study electron transport proteins, instrumentation, application and theory of DNP as well as structural investigations of amyloid fibrils using solid-state NMR spectroscopy.

Previously, he was a Postdoctoral Associate at the Francis Bitter Magnet Laboratory at MIT in the Group of Prof. Robert Griffin. In this position he was working on theory and instrumentation for high-field DNP, including development of new polarizing agents as well as applying DNP-NMR spectroscopy to study low-gamma nuclei such as 13C and 2H. He has extensive experience in designing and manufacturing instrumentation required for high-field DNP-NMR spectroscpy, such as low-temperature ssNMR probes, corrugated waveguides and microwave sources as well as their control systems. He completed his master’s degree and doctoral thesis in the group of Prof. Thomas Prisner at the Johann Wolfgang Goethe-University in Frankfurt, Germany.

Selected Publications

For a complete publication list please please visit Google Scholar or PubMed.

Dynamic Nuclear Polarization (DNP-NMR)

  1. Keller, Timothy J., Alexander J. Laut, Jagadishwar Sirigiri, and Thorsten Maly. “High-Resolution Overhauser Dynamic Nuclear Polarization Enhanced Proton NMR Spectroscopy at Low Magnetic Fields.” Journal of Magnetic Resonance 313 (March 2020): 106719. https://doi.org/10.1016/j.jmr.2020.106719.

  2. Ryan, Herbert, Jan van Bentum, and Thorsten Maly. “A Ferromagnetic Shim Insert for NMR Magnets – Towards an Integrated Gyrotron for DNP-NMR Spectroscopy.” Journal of Magnetic Resonance 277 (2017): 1–7. http://dx.doi.org/10.1016/j.jmr.2017.01.021.

  3. Review: Maly, Thorsten, Galia T. Debelouchina, Vikram S. Bajaj, Kan-Nian Hu, Chan-Gyu Joo, Melody L. MakJurkauskas, Jagadishwar R. Sirigiri, et al. “Dynamic Nuclear Polarization at High Magnetic Fields.” The Journal of Chemical Physics 128 (2008): 052211–19. https://doi.org/10.1063/1.2833582.

  4. Maly, T., D. Cui, R. G. Griffin, and A. F. Miller. “1H Dynamic Nuclear Polarization Based on an Endogenous Radical.” Journal of Physical Chemistry B 116 (June 21, 2012): 7055–65. https://doi.org/10.1021/jp300539j.

  5. Maly, T., and J. R. Sirigiri. “Simplified THz Instrumentation for High-Field DNP-NMR Spectroscopy.” Applied Magnetic Resonance 43 (July 1, 2012): 181–94. https://doi.org/10.1007/s00723-012-0360-7.

  6. Maly, Thorsten, Anne-Frances Miller, and Robert G. Griffin. “In Situ High-Field Dynamic Nuclear Polarization - Direct and Indirect Polarization of 13C Nuclei.” Chemphyschem 11 (2010): 999–1001.

  7. Maly, Thorsten, L. B. Andreas, and R. G. Griffin. “2H-DNP-Enhanced 2H-13C Solid-State NMR Correlation Spectroscopy.” Physical Chemistry Chemical Physics 12 (2010): 5872–78.

  8. Matsuki, Yoh, Thorsten Maly, Olivier Ouari, Hakim Karoui, Francois Moigne Le, Egon Rizzato, Sevdalina Lyubenova, et al. “Dynamic Nuclear Polarization with a Rigid Biradical.” Angewandte Chemie International Edition 48 (2009): 4996–5000.

  9. Maly, T., J. Bryant, D. Ruben, and R. G. Griffin. “A Field-Sweep/Field-Lock System for Superconducting Magnets–Application to High-Field EPR.” Journal of Magnetic Resonance 183 (December 2006): 303–7.

Electron Paramagnetic Resonance (EPR) Spectroscopy

  1. Dev, Bodhayan, Charan Raj Gujjala, and Thorsten Maly. “Thermo-Mechanical Analysis of a Probe for Electron Paramagnetic Resonance Spectroscopy Operating at Cryogenic Temperatures.” Review of Scientific Instruments 90, no. 4 (April 2019): 045123. https://doi.org/10.1063/1.5088695.

  2. Review: Th. Maly, K. Zwicker, A. Cernescu, U. Brandt and T. F. Prisner, New pulsed EPR methods and their application to characterize mitochondrial complex I, Biochim Biophys Acta, 2009, 1787(6), 584-592 DOI: 10.1016/j.bbabio.2009.02.003

  3. Review: S. Lyubenova, Th. Maly, K. Zwicker, U. Brandt, B. Ludwig and T. Prisner, Multifrequency Pulsed Electron Paramagnetic Resonance on Metalloproteins, Accounts of Chemical Research, 2009, 43(2) 181-189 DOI: 10.1021/ar900050d

  4. Th. Maly and T. F. Prisner, Relaxation Filtered Hyperfine Spectroscopy (REFINE), Journal of Magnetic Resonance, 2004, 170 (1), 88 - 96 DOI: 10.1016/j.jmr.2004.06.003

  5. Th. Maly, F. MacMillan, K. Zwicker, N. Kashani-Poor, U. Brandt and T. F. Prisner, Relaxation filtered hyperfine (REFINE) spectroscopy: A novel tool for studying overlapping biological EPR signals applied to mitochondrial Complex I, Biochemistry , 2004, 43 (13), 3969-3978 DOI: 10.1021/bi035865e

  6. P. Faller, Th. Maly, A. W. Rutherford and F. MacMillan, Chorophyll and Carotenoid Radicals in Photosystem II Studied by Pulsed ENDOR, Biochemistry, 2001, 40 (2), 320-326 DOI: 10.1021/bi002029l

Nuclear Magnetic Resonance (NMR) Spectroscopy

  1. M. J. Bayro, Th. Maly, N. R. Birkett, C. E. MacPhee, C. M. Dobson and R. G. Griffin, High-Resolutiion MAS NMR Analysis of PI3-SH3 Amyloid Fibrils: Backbone Conformation and Implications for Protofilament Assembly and Structure, Biochemistry, 2010, 49(35) 7474-7484 DOI: 10.1021/bi100864t

  2. M. J. Bayro, Th. Maly, N. R. Birkett, C. M. Dobson and R. G. Griffin, Long-Range Correlations between Aliphatic 13C Nuclei in Protein MAS NMR Spectroscopy, Angewandte Chemie International Edition, 2009, 48(31), 5708-5710 DOI: 10.1002/anie.200901520