Hi everyone,
I hope you are all having a wonderful week. I would like to invite you to the next International EPR society virtual seminar, which will occur on Wednesday, May 15th. Thomas Schmidt from the National Institute of Health, USA, will present his work on:
Global Fitting of Biomolecular DEER Data and its Application towards Protein Structure, Dynamics and Kinetics
Conformational substates of proteins play a key role in protein folding and molecular recognition that ultimately results in conformational exchange under equilibrium and nonequilibrium conditions. In the context of large interdomain rearrangements associated with ligand binding, the free energy landscape describing the transition from the apo form to the bound form, just as in protein folding, is likely to be rugged with numerous local minima along the pathway. Here, we provide simple tools to help you build complex fitting models for non-linear least-squares problems and apply these models to DEER data. This section gives an overview of the concepts and describes how to set up and perform simple fits. Some basic knowledge of Python and modeling data are assumed ? this is a tutorial on why or how to perform a minimization or fit data, and is aimed at explaining how to use global analysis to answer biomolecular questions by DEER spectroscopy.
Webinar details:
Time: Wednesday, May 15th, 2024, 6:00 AM California/ 9:00 AM Boston/ 3:00 PM Paris/ 7:30 PM Delhi
Webinar Link: https://fsu.zoom.us/j/95942948386?pwd=WHM0T3ZyL1pEQzFaRnRnYVdBZUdJdz09
Password: IVEM
Feel free to forward this invitation to your groups and any other interested colleagues. More information can be found on our website, including information on how to join our mailing list and links to previous seminars on our youtube channel:
https://www.eprseminars.org
If you have any questions, feel free to contact anyone on the IVEM team, see the about us section of our website for contact information.
With warm regards,
Joseph
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End of ssnmr Digest, Vol 50, Issue 2