Norcott, Philip L. “Selective NMR Detection of Individual Reaction Components Hyperpolarised by Reversible Exchange with Para-Hydrogen.” Physical Chemistry Chemical Physics 24, no. 22 (June 8, 2022): 13527–33.
https://doi.org/10.1039/D2CP01657E.
NMR spectroscopy can sometimes be hampered by two inherent weaknesses: low sensitivity and overlap of signals in complex mixtures. Hyperpolarisation techniques using para-hydrogen (including the method known as SABRE) can overcome this sensitivity problem, but cannot circumvent spectral overlap. Conversely, a recently described selective excitation technique (known as DREAMTIME) can overcome overlap in mixtures, but suffers from a decrease in sensitivity. Here we demonstrate the combination of these two methods in a single approach termed SABRE-DREAM, to selectively provide hyperpolarised signals of user-specified components of a chemical reaction, where otherwise overlapping 1H signals would hinder reaction monitoring or analysis.