Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator

Published: March 31, 2021

Ellermann, Frowin, Andrey Pravdivtsev, and Jan-Bernd Hövener. “Open-Source, Partially 3D-Printed, High-Pressure (50-Bar) Liquid-Nitrogen-Cooled Parahydrogen Generator.” Magnetic Resonance, 2021, 14.

The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen (pH2)-based hyperpolarization approaches are less cost-intensive, are scalable, and offer high throughput. However, a pH2 generator is necessary. Available commercial pH2 generators are relatively expensive (EUR 10 000–150 000). To facilitate the spread of pH2-based hyperpolarization studies, here we provide the blueprints and 3D models as open-source for a low-cost (EUR < 3000) 50-bar liquid-nitrogen-cooled pH2 generator.