A Ph.D. position is available at the Universität Leipzig, Institut für Medizinische Physik und Biophysik, with a focus on dynamics characterization with NMR relaxation and MD simulation, and development of analysis for comparison to other methods.
Characterizing motion on the molecular level is critical to understanding stability and function of a wide range of problems ranging from biology to energy to materials. However, obtaining sufficient dynamics information to completely characterize motion of a system is not trivial. Experiments return information for a limited timescale window, yielding data that is not straightforward to connect to a complete model of motion. Ideally, multiple experimental methods should be combined, in addition to molecular simulation, to span multiple timescales, and yield a “movie” of overall motion.
In this project, we will develop methods of comparative analysis between experiments and simulation, and apply these to the characterization of the dynamics. This will include development of analysis methods to yield quantitatively comparable parameters between nuclear magnetic resonance (NMR), molecular dynamics simulation (MD), Förster Resonance Energy Transfer (FRET), and dielectric spectroscopy. Methodology will be tested on model systems, but eventually applied to dynamics in G-protein coupled receptors, where multiple time- and length-scales will be probed using NMR, MD, and FRET.
The successful candidate will be responsible for performing NMR experiments, will support in the development of software for comparative analysis between methods, and will perform data analysis from NMR, MD, FRET, and dielectric spectroscopy.
About the position
The successful candidate will work directly under Dr. Albert Smith. The candidate will also benefit from close collaboration with the groups of Daniel Huster and Peter Hildebrand (Institut für Medizinische Physik und Biophysik) and also with the groups of Martin Treß, Frank Cichos, and Ralf Seidel (Peter Debye Institute for Soft Matter Physics). The candidate will gain experience in biomolecular NMR, MD simulation, and also develop skills in data analysis and programming.
-Masters in physics, chemistry, biochemistry, or similar
-Good level of english
-Good knowledge of mathematics (esp. linear algebra, statistics)
-Programming experience (python, MATLAB, or similar)
-Experience in magnetic resonance
3 years, Part time (50%, with possibility of 65%), start date 01.01.2020 or as soon as possible thereafter
Contact info for Albert Smith:
Telephone: +49 341/97-15773
Please send applications by 2 Dec. 2019 including: Cover letter, Curriculum Vitae, university transcripts, and contact information for 2 references.
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