The lab of Dr. Matthew Merritt has an immediate opening for a post-doctoral research associate in NMR and metabolism. The position is funded through a newly awarded NIH P41 grant (Project title: National Resource for Advanced NMR Technology, 1P41GM122698) with pay according to the NIH scale.
High Temperature Superconducting (HTS) cold probes provide gains in signal to noise ratio that exceed current cold probe technology by a factor of two at least. In collaboration with Dr. Bill Brey at the NHMFL, the research team will commission newly built HTS probes at 600 and 800 MHz. The probes will focus on X-detection, with potential applications in 13C and 2H based methods for studying intermediary metabolism. Other possible applications include 15N detected methods for structural biology. In addition to these goals, the Merritt lab has an active program in hyperpolarization for the study of metabolic turnover in perfused organs and in vivo. Synchronization of hyperpolarization and traditional isotope methods for measuring metabolic flux is part of a long term strategy for developing new insights into metabolic control and intermediary metabolism.
The University of Florida (Gainesville) is part of the National High Magnetic Field Laboratory, and hosts a diverse array of state of the art MR and MRI equipment. The site includes 2 horizontal bore imaging systems operating at 4.7 T and 11 T. The 11 T is a 40 cm bore system, and was recently upgraded to the latest Bruker imaging console. We also host multiple vertical bore NMR systems, including a widebore 750 MHz system for imaging and spectroscopy, three 600 MHz NMR systems, and 2 dynamic nuclear polarization instruments operating at 3.35 T (HyperSense) and 5 T (a homebuilt system). An 800 MHz NMR system will be commissioned this year; this system will serve as a primary instrument for development of the new HTS probes.
Candidates with a background in chemistry, physics, or experience in NMR or MRI will be considered. A strong interest in hardware development and troubleshooting ability is strongly encouraged in the applicant.
For applications, please send a CV and a letter of motivation to firstname.lastname@example.org.
Matthew E. Merritt
Department of Biochemistry and Molecular Biology
University of Florida
PO Box 100245
Gaineville, FL 32610-0245
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