High-field dissolution dynamic nuclear polarization of [1-(13)C]pyruvic acid

Yoshihara, H.A., et al., High-field dissolution dynamic nuclear polarization of [1-(13)C]pyruvic acid. Phys Chem Chem Phys, 2016. 18(18): p. 12409-13.


[1-(13)C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-(13)C]pyruvic acid, unextrapolated solution-state (13)C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.

Might this article interest your colleagues? Share it!

Have a question?

If you have questions about our instrumentation or how we can help you, please contact us.