Dynamic Nuclear Polarization of beta-Cyclodextrin Macromolecules #DNPNMR

Caracciolo, F., et al., Dynamic Nuclear Polarization of beta-Cyclodextrin Macromolecules. J Phys Chem B, 2017. 121(12): p. 2584-2593.


1H dynamic nuclear polarization and nuclear spin-lattice relaxation rates have been studied in amorphous complexes of beta-cyclodextrins doped with different concentrations of the TEMPO radical. Nuclear polarization increased up to 10% in the optimal case, with a behavior of the buildup rate (1/TPOL) and of the nuclear spin-lattice relaxation rate (1/T1n) consistent with a thermal mixing regime. The temperature dependence of 1/T1n and its increase with the radical concentration indicate a relaxation process arising from the modulation of the electron-nucleus coupling by the glassy dynamics. The high-temperature relaxation is driven by molecular motions, and 1/T1n was studied at room temperature in liquid solutions for dilution levels close to the ones typically used for in vivo studies.

Might this article interest your colleagues? Share it!

Have a question?

If you have questions about our instrumentation or how we can help you, please contact us.