Paioni, Alessandra Lucini, Marie A M Renault, and Marc Baldus. “DNP and Cellular Solid-State NMR,” 7:12, 2018.
Solid‐state nuclear magnetic resonance (ssNMR) can provide structural information at the most detailed level and, at the same time, is applicable in highly heterogeneous and complex molecular environments, largely irrespective of solubility or crystallinity. Revolutionary developments in the field of dynamic nuclear polarization (DNP) have greatly enhanced ssNMR sensitivity. In this article, we discuss ssNMR concepts and applications that make use of these advancements and enable the study of complex biomolecular and even cellular systems at unprecedented structural resolution and molecular detail.