Kwiatkowski, G., et al., Direct hyperpolarization of micro- and nanodiamonds for bioimaging applications – Considerations on particle size, functionalization and polarization loss. J Magn Reson, 2018. 286: p. 42-51.
Due to the inherently long relaxation time of (13)C spins in diamond, the nuclear polarization enhancement obtained with dynamic nuclear polarization can be preserved for a time on the order of about one hour, opening up an opportunity to use diamonds as a new class of long-lived contrast agents. The present communication explores the feasibility of using (13)C spins in directly hyperpolarized diamonds for MR imaging including considerations for potential in vivo applications.