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[NMR] Postdoc position → Hyperpolarization at the CRMN in Lyon #DNPNMR

Generating and Transporting Hyperpolarization for preclinical MRI

A Postdoctoral position is available working in the group of Prof. Sami Jannin HMRLab on a project funded by the European Research Council, at CRMN in the city of Lyon, France.
We are looking for highly motivated candidate with strong scientific background, independence, and who enjoy teamwork. For postdoctoral positions, you must hold a PhD in Chemistry, Physics or related disciplines. Skills in will be appreciated in Nuclear magnetic resonance and possibly Dynamic nuclear polarization.

The candidate will in particular:

o   Perform low temperature DNP experiments with a functional state-of-the-art Bruker prototype polarizer, using novel hyperpolarizing materials that are synthetized in our team and that extend the lifetime of hyperpolarized MRI tracers to days (see doi:10.1038/ncomms13975doi:10.1073/pnas.1407730111, poster  here, and videos here )o   Transport hyperpolarized molecules to the preclinical MRI facility agro-resonance with a newly developed hyperpolarization transport system, and participate together with the specialized MRI team of Jean-Marie Bonny to pre-clinical imaging experiments.

The position will be open until filled with a possible starting date January-March 2021 with a one-year time commitment required and a possibility for two-years extension. 

You can get directly in touch directly with sami.jannin@univ-lyon1.fr for further details on the position, and submit your application via e-mail as a single PDF file including:
i)              a cover letter (explaining background and motivation),
ii)             your CV,
iii)            contact information of 2-3 references.

The Center for Very High Field NMR is one of the world’s leading magnetic resonance laboratories, located in the great city of Lyon, which is affiliated to the Lyon-1 University, the CNRS (French National Center for Scientific Research) and the Ecole Normale Supérieure de Lyon. The center is equipped with state-of-the-art NMR spectrometers (500 – 700 – 800 MHz, and the world’s first 1 GHz spectrometer) with two state of the art dissolution-DNP machines. It hosts research groups of worldwide-recognized excellence.

 Sami Jannin 
Professor at the Lyon 1 University 
  
Deputy Director Centre de RMN à Très Hauts Champs http://crmn-lyon.fr 
5 rue de la Doua 
69100 Villeurbanne FRANCE 
  
Team Leader Hyperpolarized Magnetic Resonance Lab http://hmrlab.eu 
  
Head of Lyon 1 University ERC support program 
  
mobile: +33 6 67 90 77 52 
office: +33 4 37 42 35 27
 We are hosting HYP21 
the 6th Hyperpolarization Conference 
in Lyon
http://hyp20.org 
 
 follow us on TwitterOrcid , and Publons 

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Post-Doctoral Position Opening – Sherwin Group: High-power arbitrary waveform generation for pulsed magnetic resonance at 240 GHz and above, with applications dependent on post-doc’s interest.

Find the complete job description here:
https://recruit.ap.ucsb.edu/JPF01895

Background: Coherent manipulation of electron spins at magnetic fields above 7 T (frequencies above 200 GHz) is required for investigations of decoherence in potential quantum bits, excitations of strongly-correlated spin systems, spintronics, and the structure and dynamics of biological macromolecules. However, with current technology, it is exceedingly difficult to generate the sequences of high-power sub-THz pulses that are required for these studies. By “slicing” a sequence of pulses from the ~kW output of UCSB’s MM-wave Free-Electron Laser, we have made significant progress towards filling this technological gap, and have demonstrated the world’s first FEL-powered electron paramagnetic resonance (EPR) spectrometer at 240 GHz. The existing “pulse slicer” uses high-power doubled Nd:YAG lasers to drive Si wafers from the insulating (transmissive) state to the conducting (reflective) state. It occupies two optical tables and is not easily reproduced.

The project: In collaboration with Bridge12, a small company in the Boston area, we have recently been funded to develop a “compact pulse slicer for high-power sub-millimeter waves.” The goal is to leverage advances in inexpensive solid-state laser and semiconductor wafer-bonding technologies to demonstrate a pulse slicer that can eventually be commercialized and deployed for use with existing submillimeter wave sources called gyrotrons to enable pulsed EPR and pulsed dynamic nuclear polarization. The team includes highly-experienced Ph. D. level scientists at UCSB, Bridge12, in the ThorLabs Crystalline Mirror Coatings division.

The job: The successful post-doc will, in close collaboration with the team, develop the optics and electronics for both reflective and transmissive elements of the compact pulse slicer, model the carrier dynamics in the semiconductor switches, perform pulse slicing experiments, and compare performance with theoretical predictions. With the pulse slicer they develop, the post-doc will be encouraged to pursue a scientific direction they are interested in within the broad range of topics under investigation in the Sherwin group. After completion of the post-doctoral job, the post-doc will be well positioned for a wide range of career options, including in academia, industry, and government labs.

Requirements: Applicants must have a Ph. D. in Physics, Applied Physics, Materials, Electrical Engineering, Physical Chemistry, or a related field of science or engineering at the time of application. Experience with developing scientific instrumentation, numerical modeling of physical phenomena, and one or more of the methodologies used in this project (for example, optics, lasers, semiconductors, microwaves, magnetic resonance) is preferred.

[NMR] Postdoctoral Fellowships: Pulmonary and Hyperpolarized Gas MRI

The Center for Pulmonary Imaging Research (https://cpir.cchmc.org) at Cincinnati Children’s Hospital Medical Center seeks to hire multiple Postdoctoral Fellows in the area of NMR and MRI relevant to lung disease. Fellows will work with a multidisciplinary team of engineers, physicians, and MR scientists to quantify lung structure and function in humans and mouse models using ultra-short echo-time (UTE) and hyperpolarized 129Xe MRI. Research involves developing pulse sequences, image analysis methods, and hardware to study a variety of diseases, including Cystic Fibrosis and Idiopathic Pulmonary Fibrosis (IPF). Research instrumentation includes 7T horizontal bore and 9.4 T vertical bore preclinical Bruker scanners, a custom-built 22-cm bore 1.5T neonatal scanner, a 1.5T Philips human scanner, and three 3T Philips scanners. We also have access to clinical MRI equipment for in-patient research, state-of-the-art NMR Metabolomics and Confocal Microscopy Cores, and a world-class engineering laboratory capable of designing and fabricating a wide range of RF coils and related hardware.

Candidates with strong backgrounds in magnetic resonance—EPR, NMR, spin exchange, or MRI—and a PhD in a relevant discipline (engineering, physics, medical physics, chemistry, etc.) are encouraged to apply. Ideal candidates will also possess expertise in one or more of the following: pulse programming, image reconstruction/analysis, scientific computing (MATLAB, C++, etc.), hardware design, in vivo imaging/spectroscopy, or hyperpolarized media.

The preferred start date will be in late August or September of 2020, but significant flexibility exists for the right candidates. To apply, provide the following materials: cover letter stating research experience and interests, curriculum vitae, contact information of 3 references, and reprints of up to 2 peer-reviewed publications. Correspondence and inquiries should be sent to:

Zackary I. Cleveland, Ph.D. (https://www.cincinnatichildrens.org/bio/c/zackary-cleveland)

Associate Professor of Radiology, Pulmonary Medicine, Pediatrics, and Biomedical Engineering at: zackary.cleveland@cchmc.org.

CINCINNATI CHILDREN’S RESEARCH FOUNDATION

CCHMC is a premier pediatric research institution with over 900 diverse and productive faculty members that consistently ranks #2 or 3 on the US News list of top Pediatric Hospitals, with the Pulmonary Division recently ranked #1. Post-doctoral fellows at CCHMC are valued for their unique interests and strengths, and are supported through our Office of Postdoctoral Affairs and Office of Academic Affairs and Career Development. Mentoring, compensation for moving expenses, support for international fellows, and training in grant writing are only a few of the features that set our program apart. Cincinnati Children’s is a respected part of the broader and vibrant Cincinnati community, which includes a thriving arts scene, affordable housing, numerous music and food festivals, college and professional sports teams, and opportunities for a wide range of outdoor activities.

Cincinnati Children’s Hospital Medical Center is an Affirmative Action/Equal Opportunity Institution

Zackary I. Cleveland, Ph.D.

Associate Professor

Center for Pulmonary Imaging Research

Division of Pulmonary Medicine, Cincinnati Children’s Hospital

Departments of Pediatrics and Biomedical Engineering, University of Cincinnati

Cincinnati Children’s Hospital Medical Center

3333 Burnet Ave., MLC-2021

Cincinnati, OH 45229

Webpage: https://cpir.cchmc.org/

Phone: (513) 803-7186

Fax: (513) 803-4783

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[NMR] 53rd Royal Society of Chemistry ESR Group Meeting – deadline approaching #DNPNMR #EPR

Dear Colleagues,

the registration deadline for the 53rd Annual Meeting of the ESR Group of the Royal Society of Chemistry is on 21 February. If you plan to attend, please register here:

http://www.esr-group.org/conferences/2020-conference-manchester/

The Meeting is the longest running EPR spectroscopy conference in the world, as well as the occasion on which the EPR Bruker Prizes are awarded for the best PhD thesis (junior level) and the best scientific accomplishment (senior level). The meeting also hosts IES Poster Prizes, and the JEOL Medal, awarded for the best student presentation. In the annual cycle of the EPR spectroscopy community, this conference is the central event.

This year’s Meeting will take place in Manchester between 29th Mar and 2nd Apr 2020. The registration is open and may be accessed via the link above.

Best wishes,

Ilya.

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Dr Ilya Kuprov FRSC

Associate Professor of Chemical Physics

Secretary to the RSC ESR Spectroscopy Group

Associate Editor, Science Advances

Office 3041, Building 30,

School of Chemistry, FNES,

University of Southampton,

Southampton, SO17 1BJ, UK.

Tel: +44 2380 594 140

Email: i.kuprov@soton.ac.uk

Web: http://spindynamics.org

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Molecules – Special Issue “Hyperpolarized Molecules for Applications in Chemistry and Biomedicine”

Dear Colleagues,

I am pleased to announce that the journal Molecules (ISSN 1420-3049, IF 3.098) is currently running an NMR-related special issue entitled “Hyperpolarized Molecules for Applications in Chemistry and Biomedicine”. Molecules is fully open access and is a partner of the Swiss Chemical Society. Open access is supported by the authors and their institutes, and an Article Processing Charge (APC) of 1800 CHF applies to accepted papers. 

We welcome you to submit abstracts before 31 July 2019. Given the fast development of hyperpolarization technology, I was able to negotiate with the journal the following discounts to papers: two 50% discounts, three 30% discounts, and five 20% discounts.

For more information about the Special Issue, please see: https://www.mdpi.com/journal/molecules/special_issues/hyperpolarized_molecules

The final due date for the contribution will be 31 August 2019, and manuscripts can be submitted from now until the deadline.

We look forward to hearing from you soon.

Warm regards,

Danila Barskiy

Danila A. Barskiy, PhD

Postdoctoral Scholar

danilabarskiy.com/

Pines Lab

University of California, Berkeley

QB3 Chemistry Department

227B Stanley Hall

Berkeley, CA 94720-3220

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[IES] New Award announcement from IES – Best paper Award

Dear (active) IES member

The IES announces the NEW 2019 IES Best Paper Award. The IES looks forward to highlighting exciting advances and breakthrough development in the broad area of EPR and ESR. This award will be given to up 2 publications per year, and the first author recognized with this award. The expectation is that the first author is a young scientist. Nomination can be made by any IES member, faculty or student. If self-nomination is made, it can be made only by the first author or the corresponding author. Nomination by first author should be accompanied by letter from the corresponding author explaining the role of the first author. Deadline for this Award is April 1st 2019.

The application material that includes the following items should be packed into a single PDF document and emailed to the IES secretary ab359@technion.ac.il .

1) Cover letter not exceeding 1 page with your name, role and affiliation, full citation of the paper and explanation as to why this paper represents an exciting advance and breakthrough development in the broad area of EPR and ESR.

2) PDF of the nominated publication.

3) If applicable, letter from the corresponding author, not exceeding 1 page, explaining the role of the first author.

Regards

Aharon Blank

Schulich Faculty of Chemistry

Technion – Israel Institute of Technology.

Haifa 32000

Israel

ab359@tx.technion.ac.il

Phone: +972-4-829-3679

fax: +972-4-829-5948

http://mr-lab.technion.ac.il/

A message from the International EPR Society

Below is a message from the International EPR Society to members for the EPR and Magnetic Resonance Community. I typically don’t post these kind of advertisements but I do believe the International EPR Society has done a lot of great work for the community over the many years.

Take a look at https://www.ieprs.org. Membership fees are very low and the EPR Newsletter is a nice treat.

Dear EPR users,

To continue to have a vibrant, diverse, and active EPR community, we will all benefit from a scientific organization that offers a support and communication infrastructure for EPR — this is what the International EPR Society (https://www.ieprs.org) aspires to offer. 

The most familiar faces of IES may be the EPR Newsletters and the Silver and Gold Medals for EPR. 

IES is the only international scientific organization that represents the whole range of important research fields of electron paramagnetic resonance (EPR) spectroscopy and EPR imaging (EMRI). These methods are used as the main research tools over a very wide range of fields, including physics, chemistry, life sciences, materials research and medicine.

IES is a world-wide association of scientists, and the IES mailing list serves the community to help spread EPR-related information (jobs, post-doc and PhD positions, conferences, etc.) to the world-wide EPR community. It provides public networking, available to IES members, where one can post messages via the EPR Newsletter (EPRNL), the official IES publication. EPRNL not only provides information on the availability of second-hand EPR instrumentation, it also publishes advertisements of prominent manufacturers of EPR instrumentation.

Members of IES have free access to the EPRNL! See: http://www.epr-newsletter.ethz.ch

IES also awards prizes and honors for outstanding contributions to EPR spectroscopy, from senior to young investigators! The newly created IES poster prizes honor excellent young scientists and PhD students for their contributions to international EPR conferences. All these achievements are reported in the EPRNL, and you can find more about “Why IES” here: http://www.ieprs.org/whyjoin.php

The member fees are encouragingly low: $6/year for students, $12/year for emeritus and post-doctoral fellows, and $36/year for full members. We will be happy if you paid the membership dues for several years. See: http://www.apes-ies2018.org/registration

Your membership of the IES is what will keep IES relevant, vibrant and impactful, and give IES the necessary tools to be responsive to the ever emerging field of EPR spectroscopy. 

Sincerely,

Songi Han, Vice President (America) of IES

Thomas Prisner, President of IES

Best Practices for Scientific Computing

Ever since I started in Magnetic Resonance Spectroscopy I did a lot of programming in Matlab, C, C++, LabVIEW, html,  and more recently Python. All of it is picked along the way, without ever having a class in programming. With that a lot of bad habits evolve over the years. No matter what programming language is your currently choice, take a look at this very nice article. If you don’t want to read through the whole thing take a look at Box 1 on page 2 to get an idea of the basics.

Wilson G, Aruliah DA, Brown CT, Chue Hong NP, Davis M, Guy RT, et al. (2014) Best Practices for Scientific Computing. PLoS Biol 12(1): e1001745. https://doi.org/10.1371/journal.pbio.1001745

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001745

Scientists spend an increasing amount of time building and using software. However, most scientists are never taught how to do this efficiently. As a result, many are unaware of tools and practices that would allow them to write more reliable and maintainable code with less effort. We describe a set of best practices for scientific software development that have solid foundations in research and experience, and that improve scientists’ productivity and the reliability of their software.

PhD scholarship in Metabolomics using Dissolution DNP-NMR

Detailed information can be found here: PhD Sholarship in dDNP

A PhD scholarship is available in the Centre for Hyperpolarization in Magnetic Resonance (HYPERMAG) at DTU Elektro, starting at the beginning of 2018. 

HYPERMAG is a Centre of Excellence founded by the Danish National Research Foundation. We conduct research in the field of biomedical engineering with the aim of conducting real time functional imaging by tracking metabolic processes with isotope labelled tracers. 

The centre specializes in a technology, hyperpolarization with dissolution dynamic nuclear polarization (dDNP), that produce signal enhancement on Nuclear Magnetic Resonance (NMR) by many orders of magnitude. This large signal increase allows direct detection of metabolism in living objects from cell to man. In the Biology group, in particularly, we focus on developing new applications that exploit signal-enhanced tracers in the observation of transient states in metabolic networks. 

The subject of the PhD project is stable isotope resolved metabolomics within the framework of dDNP NMR. The aim is to establish and execute data acquisition, analysis and interpretation strategies for quantitative dDNP NMR analysis of metabolites in cellular systems. Using the developed and demonstrated tools human tissue samples will be analysed with dDNP NMR and evaluated in the context of metabolomics research.

Responsibilities and tasks 

The PhD candidate will be working with interdisciplinary experimental research rooted in biophysics. 

The project will include: 

  • Establishment and validation of NMR acquisition strategy and data analysis methods 
  • Development of data interpretation methods for quantitative dissolution DNP NMR 
  • Demonstration of developed tools on metabolite extract data from pathogen-host bio-systems 
  • Ex vivo study of stable isotope resolved metabolism analysis using tissue samples. 

We seek an enthusiastic candidate with background in biotechnology, biophysics or equivalent to carry out this interdisciplinary project. Knowledge within dissolution DNP and NMR is preferred. Good communication skills in English, both written and spoken, are required. 

Qualifications 

Candidates should hold a MSc in engineering or a similar degree with an academic level equivalent to the MSc in engineering. 

Approval and Enrolment

The scholarship for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide: http://www.dtu.dk/english/Education/PhD/Rules/PhDguide.

Assessment

The assessment of the applicants will be made by Senior Scientist Mathilde Hauge Lerche and Associate Professor Pernille Rose Jensen. Final assessment will be on the basis of an interview. 

You are more than welcome to contact us by email: mhauler@elektro.dtu.dk

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and an academic freedom tempered by responsibility. 

Salary and appointment terms

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed with the relevant union. The period of employment is 3 years. 

You can read more about career paths at DTU here: http://www.dtu.dk/english/career/meet-our-people/career-paths.

Further information 

Further information may be obtained from Senior Scientist Mathilde Hauge Lerche, tel.: +45 5362 4555. 

You can read more about Center for Hyperpolarization in Magnetic Resonance on http://www.hypermag.dtu.dk.

Application

Please submit your online application no later than 5 November 2017 (Local time). Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link “Apply online”, fill in the online application form, and attach all your materials in English in one pdf file. 

The file must include: 

Candidates may apply prior to obtaining their MSc, but cannot begin before having received it. 

All qualified candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

Have a question?

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