Dear NMR community;
A postdoctoral position is available in my laboratory at UC Irvine (please see attached description.) The project involves developing and using multidimensional sequences for incorporating 2H into protein structure determination experiments in solids, using our unique quadruple-resonance MAS probe operating at 800 MHz. Anyone who is interested should email Rachel Martin (email@example.com). The formal application can be found on UCI’s website at https://recruit.ap.uci.edu/JPF05254. I will also be at the Alpine conference in Chamonix if any potential candidates who are attending the meeting would like to discuss the project with me.
School of Physical Sciences
Department of Chemistry
Position: Postdoctoral Position – Solid-State NMR
A postdoctoral position is available at the University of California, Irvine in the area of protein structure determination by solid-state NMR, specifically of the aggregates of eye lens proteins found in cataract disease. The goal of this NIH-funded project is to develop and use advanced solid-state NMR methods for the study of complicated protein aggregates. The group has access to an 800 MHz instrument, equipped with solution-state and MAS probes, including a unique crossed-coil 1H/13C/2H/15N MAS probe purpose-built for these experiments. We also have two dedicated 500 MHz NMR instruments (one solids and one liquids), as well as a fully-equipped molecular biology
laboratory for sample preparation. The ideal candidate will be experienced in protein structure determination by MAS and interested in using novel instrumentation to solve biological problems.
The project supports solid-state NMR methods development and structure determination of wild-type human γS-crystallin in the transparent hydrogel state found in the healthy eye lens, as well as the aggregates formed by UV-light damaged proteins and cataract-related variants. The Martin group is experienced in preparation of crystallin proteins: isotopically labeled samples of the transparent hydrogel of the native crystallin and the aggregates associated with cataract have been prepared. As part of this project, new NMR methodology will be developed to investigate the structural factors related to γS-crystallin stability and solubility. Differential isotope labeling of peptide binders and variant crystallins will be used to identify specific residues involved in altered intermolecular interactions, followed by full structure determination of cataract aggregates. Extensive use will be made of deuterated samples and deuterium NMR in the context of multidimensional NMR experiments.
Candidates must have (or be about to earn) a Ph.D. in Chemistry, Physics, or a related discipline, and have experience solving protein structures using MAS NMR. Previous experience with pulse sequence development is desirable but not required.
Please apply online at https://recruit.ap.uci.edu/apply/JPF05254 with a cover letter that also describes your immediate and long-term research goals, a curriculum vitae including publications list, and names for three letters of reference (please do not solicit letters). Review of applications will begin on Oct 1, 2019 and will continue until the position is filled.
The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.
Rachel W. Martin
Professor of Chemistry
and Molecular Biology & Biochemistry
University of California, Irvine
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University of Lille invites applications for a 3-year PhD position in the area of solid-state NMR of optoelectronic materials. The research project, funded by the University of Lille and the region Haute-de-France, will start from 1 October 2019. PhD student will be supervised by Dr. Manjunatha Reddy in close collaboration with Dr. Laurent Delevoye and Prof. Olivier Lafon at the Department of Chemistry, Solid-State Chemistry Division.
Send your application as a single pdf containing cover letter, CV and references, and transcripts directly to firstname.lastname@example.org ; email@example.com ; firstname.lastname@example.org before 31 May 2019. To be considered for this PhD positon the applicant must have (i) completed Master’s degree in Chemistry, Physics or Material Science by August 2019, (ii) experience in synthesis of hybrid materials into thin films and analyses by surface and bulk characterization techniques, and (iii) excellent communication skills in English. Proficiency in French language is a plus but not obligatory. For informal queries about the position please contact email@example.com
Research project and objectives: The quest for developing high-performance materials for optoelectronics applications is growing faster than ever. Last decade has seen a spike in the development of π-conjugated materials and hybrid perovskite halides as low-cost and efficient solar absorbers, enabling power conversion efficiencies over 15% and 23%, respectively. Such advancements in material syntheses necessitate the requirement for in-depth analyses of reactive heterogeneous surfaces and interfaces, particularly at high sensitivity and resolution. The objectives of this project are to develop and acquire deep new understandings of structure-function relationships in optoelectronic materials. Notably, low-dimensional hybrid perovskite halides will be synthesized in the form of layered structures by incorporating organic and inorganic building blocks. The key is to combine solvothermal synthesis with in situ or ex situ solid-state NMR characterization techniques so as to gai!
n insight into the evolution of molecular order at organic-inorganic interfaces. Complementary information on the material compositions and structures will be obtained by X-ray and neutron scattering techniques, surface probes (electron microscopy and X-ray photoelectron spectroscopy) and depth profiling using secondary-ion mass spectrometry (SIMS). All of these fundamental understandings will be used to rationalize the material design in order to augment the stability, performance and propensity towards enhanced optical and electronic properties.
Host laboratory and infrastructure: Research will be carried out at the Department of Chemistry – Solid-state Chemistry Division, University of Lille. City of Lille is located in northwestern France, easily accessible from/to Paris, Brussels and London by train. Department of Chemistry offers excellent training courses and hosts state-of-the-art research facilities; synthesis chemistry apparatus and analytical facilities for surface and bulk characterization of materials. Of particularly relevant to this project, NMR center in Lille is equipped with high field (800 and 900 MHz) spectrometers and placed an order for a 1.2 GHz spectrometer for the characterization of material solids, which is a unique opportunity to undertake this interdisciplinary research project.
G. N. Manjunatha Reddy
Assistant Professor of Chemistry
Solid-State Chemistry Division
Ecole Nationale Supérieure de Chimie de Lille
Cité Scientifique, 218 Bâtiment C7-BP 90108
Villeneuve D’Ascq 59650
Tel: +33 (0)3 2033 5907
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