Danila Barskiy - Chemistry using Parahydrogen NMR Tutorial - Tuesday, September 20, 11 am Boston or 5pm Paris or 8:30pm Delhi

Published: Tuesday, 13 September 2022 - 10:00 -0400

Author: Thorsten Maly

Dear NMR Enthusiasts,

We hope you had a great summer this year and enjoyed all the exciting magnetic resonance conferences, including our first Twitter conference. In case you missed it, you can always find the link to the Twitter posters/videos provided on our website.

We will begin our online tutorial series starting September 20, 2022. This semester we have even more diverse tutorials planned, which will be delivered by leading scientists from around the world. The 51st Global NMR Educational Tutorial will be given by Danila Barskiy, Research Group Leader at the Helmholtz Institute, Johannes Gutenberg University Mainz, Germany, on the topic:

“Parahydrogen-based Exchange Chemistry for Next-Generation Magnetic Resonance”

Nuclear magnetic resonance (NMR) is undergoing renaissance: the advent of hyperpolarization techniques allows enhancing weak nuclear signals by orders of magnitude, making possible measurements which were previously considered impractical, e.g., monitoring metabolism in vivo. Since large magnetic fields are no longer necessary to generate large nuclear magnetization, non-conventional signal detection approaches are now being considered as an alternative to conventional, inductive schemes. In my talk, I will focus on our recent work demonstrating that parahydrogen-based spin chemistry (in particular, SABRE-relay and PHIP-X methods) can be used for generating hyperpolarized analytes for benchtop (1 tesla) and ultralow-field (<100 nT) NMR. The presented exchange-based methods are applicable to a wide range of metabolites as demonstrated here for urea (15NP >1%), alcohols, aminoacids, ammonium, glucose possessing exchangeable protons and have potential applications for chemical analysis and measuring NMR spectra from natural extracts and biological fluids using portable spectroscopic tools.

Speaker’s biography:
2012 — 2015: PhD - Novosibirsk University, Russia
2015 — 2017: postdoc - Vanderbilt University, USA
2017 — 2020: postdoc - University of California Berkeley, USA
2020 — present: - Research Group Leader at the Helmholtz Institute, Germany.

Webinar details:
Time: Tuesday, September 20, 2022, 8:00AM California or 11:00 am Boston or 5:00 PM Paris or 8:30 PM Delhi

New Link: https://epfl.zoom.us/j/81308524368

Best regards,
Global NMR Discussion Meetings

YouTube: https://www.youtube.com/c/GlobalNMRDiscussionMeetings/videos

Current organizers:
Adrian Draney (Creighton Uni., Chemistry)
Amrit Venkatesh (Lyndon Emsley Lab, EPFL)
Asif Equbal (New York Uni., Abu Dhabi)
Blake Wilson (Robert Tycko Lab, NIH)
Michael Hope (Lyndon Emsley Lab, EPFL)
Mouzhe Xie (Maurer Lab, Uni. Chicago)
Nino Wili (Niels Chr Nielsen Lab, Aarhus Uni.)

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