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PhD scholarship in Metabolomics using Dissolution DNP-NMR

Detailed information can be found here: PhD Sholarship in dDNP

A PhD scholarship is available in the Centre for Hyperpolarization in Magnetic Resonance (HYPERMAG) at DTU Elektro, starting at the beginning of 2018. 

HYPERMAG is a Centre of Excellence founded by the Danish National Research Foundation. We conduct research in the field of biomedical engineering with the aim of conducting real time functional imaging by tracking metabolic processes with isotope labelled tracers. 

The centre specializes in a technology, hyperpolarization with dissolution dynamic nuclear polarization (dDNP), that produce signal enhancement on Nuclear Magnetic Resonance (NMR) by many orders of magnitude. This large signal increase allows direct detection of metabolism in living objects from cell to man. In the Biology group, in particularly, we focus on developing new applications that exploit signal-enhanced tracers in the observation of transient states in metabolic networks. 

The subject of the PhD project is stable isotope resolved metabolomics within the framework of dDNP NMR. The aim is to establish and execute data acquisition, analysis and interpretation strategies for quantitative dDNP NMR analysis of metabolites in cellular systems. Using the developed and demonstrated tools human tissue samples will be analysed with dDNP NMR and evaluated in the context of metabolomics research.

Responsibilities and tasks 

The PhD candidate will be working with interdisciplinary experimental research rooted in biophysics. 

The project will include: 

  • Establishment and validation of NMR acquisition strategy and data analysis methods 
  • Development of data interpretation methods for quantitative dissolution DNP NMR 
  • Demonstration of developed tools on metabolite extract data from pathogen-host bio-systems 
  • Ex vivo study of stable isotope resolved metabolism analysis using tissue samples. 

We seek an enthusiastic candidate with background in biotechnology, biophysics or equivalent to carry out this interdisciplinary project. Knowledge within dissolution DNP and NMR is preferred. Good communication skills in English, both written and spoken, are required. 

Qualifications 

Candidates should hold a MSc in engineering or a similar degree with an academic level equivalent to the MSc in engineering. 

Approval and Enrolment

The scholarship for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide: http://www.dtu.dk/english/Education/PhD/Rules/PhDguide.

Assessment

The assessment of the applicants will be made by Senior Scientist Mathilde Hauge Lerche and Associate Professor Pernille Rose Jensen. Final assessment will be on the basis of an interview. 

You are more than welcome to contact us by email: mhauler@elektro.dtu.dk

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and an academic freedom tempered by responsibility. 

Salary and appointment terms

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed with the relevant union. The period of employment is 3 years. 

You can read more about career paths at DTU here: http://www.dtu.dk/english/career/meet-our-people/career-paths.

Further information 

Further information may be obtained from Senior Scientist Mathilde Hauge Lerche, tel.: +45 5362 4555. 

You can read more about Center for Hyperpolarization in Magnetic Resonance on http://www.hypermag.dtu.dk.

Application

Please submit your online application no later than 5 November 2017 (Local time). Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link \”Apply online\”, fill in the online application form, and attach all your materials in English in one pdf file. 

The file must include: 

Candidates may apply prior to obtaining their MSc, but cannot begin before having received it. 

All qualified candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

Transportable hyperpolarized metabolites #DNPNMR

This article describes an elegant way to increase the throughput of a hyperpolarizer by storing the hyperpolarized materials separated from the polarizing agents.

Ji, X., et al., Transportable hyperpolarized metabolites. Nat Commun, 2017. 8: p. 13975.

https://www.ncbi.nlm.nih.gov/pubmed/28072398

Nuclear spin hyperpolarization of 13C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the short lifetime of the hyperpolarized magnetization (typically <1 min), the polarization process must be carried out close to the point of use. Here we introduce a concept that markedly extends hyperpolarization lifetimes and enables the transportation of hyperpolarized metabolites. The hyperpolarized sample can thus be removed from the polarizer and stored or transported for use at remote MRI or NMR sites. We show that hyperpolarization in alanine and glycine survives 16 h storage and transport, maintaining overall polarization enhancements of up to three orders of magnitude.

[NMR] Nobel Prize winner Nico Bloembergen passed away at age 97

From the Ampere Magnetic Resonance List:

Dear colleagues,

Last week, Nobel laureate Professor Nicolaas Bloembergen, a pioneer in the field of NMR and laser spectroscopy passed away at age of 97. As an undergraduate Bloembergen studied Physics at Utrecht University from 1938 to 1943 and received his PhD in Physics from Leiden University with C.J. Gorter in 1948 on the topic of Nuclear Magnetic Relaxation. His thesis resulted in the famous BPP (Bloembergen, Purcell and Pound) paper which still serves as a point of departure for understanding many NMR relaxation experiments. In 1973 he returned to Leiden and occupied the Lorentz Chair in Physics. In 1981, he was awarded the Nobel Prize in Physics for his work in coherent optics. In 2001 in honour of his achievements, the NMR group at Utrecht University named their laboratory the Bloembergen Building.

For further information on a true scientific giant, please look out for an obituary written by C. Luchinat, R. Boelens, and R. Kaptein that will appear on the Ampere website and in the Ampere newsletter soon.

Also, please see, for example:

https://www.uu.nl/en/news/uu-alumnus-and-nobel-prize-winner-nico-bloembergen-passed-away

https://www.uu.nl/en/research/nicolaas-bloembergen

https://www.universiteitleiden.nl/en/news/2017/09/nobel-prize-winner-nicolaas-bloembergen-97-has-passed-away

https://www.washingtonpost.com/local/obituaries/nicolaas-bloembergen-winner-of-nobel-prize-in-physics-dies-at-97/2017/09/09/2e8af4dc-9335-11e7-8754-d478688d23b4_story.html?utm_term=.d28e406578ee

Best wishes,

Marc Baldus

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[NMR] MOOC on NMR, Feb. 20 to Apr. 17, 2017

From the Ampere Magnetic Resonance List

Dear colleagues,

In 2015, the Massive Open Online Course (MOOC) “Nuclear Magnetic Resonance (NMR), a Compass to Nanoworld” hosted on the FUN platform was one of the first MOOCs covering the subject of NMR.

It is our great pleasure to announce that the second! offering of this MOOC is now open for free registration. 

This MOOC in English aims at providing the basic knowledge about NMR and an overview of its applications to students and professionals who want to enter this field.

Topics to be covered include:

• Basic principles and practice of NMR spectroscopy;

• Solution NMR of small molecules;

• NMR of proteins and sugars;

• Basic principles and practice of solid-state NMR spectro scopy;

• NMR characterization of materials (glasses, heterogeneous catalysts, battery materials).

The courses will be held from February 20 to April 17, 2017. For this course, about 2-3 hours of work per week are expected. MOOC participants will learn through video lectures and online discussions with peers and professors. The acquired knowledge will be tested through weekly quizzes.

This course does not require previous knowledge about NMR spectroscopy. Nevertheless, the participants should have a background in basic chemistry (chemical elements, molecular structure) and in basic physics (magnetism, basic spectroscopy).

The teachers of this MOOC are Olivier Lafon (coordinator), Cédric Lion, Emmanuel Maes, Frédérique Pourpoint, Robert Schneider and Julien Trébosc. They belong to the University of Lille and the CNRS. The University of Lille is part o f the French network of high-field NMR facilities (http://www.ir-rmn.f! r/) and hosts 800 and 900 MHz NMR spectrometers for the study of liquids and solids. It has also been selected to host the first 1.2 GHz NMR spectrometer to be installed in France. 

Please distribute this announcement to your students as well as to your colleagues who may be interested.

If you are interested, please register through the website 

https://www.fun-mooc.fr/courses/lille1/54002S02/session02/about

You can already watch the MOOC trailer on this website. 

With kind regards,

Olivier Lafon, Cedric Lion, Emmanuel Maes, Frederique Pourpoint, Robert Schneider and Julien Trebosc

— 

________________________________________________________________

Olivier Lafon

Professor

Department of chemistry

University of Lille – Institut Universitaire de France

F-59652, Villeneuve d\’Ascq, Cedex, France

Tel: 33 3 20 43 41 43 Fax : 33 3 20 43 68 14

email: olivier.lafon@univ-lille1.fr

web page: http://uccs.univ-lille1.fr/index.php/annuaire/15-fiches-personnels/171-lafon-olivier

twitter profile: https://twitter.com/LafonOlivier

group web page: http://uccs.univ-lille1.fr/index.php/chimie-du-solide/verres-et-methodologie-rmn

____________________________________________________ ___________ 

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[NMR] MR Imaging and Spectroscopy Research Staff Scientist position at the U.S. National High Magnetic Field Laboratory / University of Florida

From the Ampere Magnetic Resonance List

MR Imaging and Spectroscopy Research Staff Scientist

Advanced Magnetic Resonance Imaging and Spectroscopy Facility and National High Magnetic Field Laboratory

University of Florida

The Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) Facility at UF seeks an MR imaging and spectroscopy scientist for the permanent research staff position of Core Research Facility Manager/Director for ≥ 11.74 Tesla vertical bore NMR/MRI instrumentation. Minimum qualifications include a Ph.D., or equivalent, in Physical Sciences or Engineering, with a demonstrated experience and expertise in techniques and applications of high field MR imaging and spectroscopy. Previous experience in pulse sequence design and implementation as well as data processing is needed. Experience working with live animals is desirable.

The successful candidate will be expected to work with the staff of the AMRIS Facility to maintain optimal instrument performance and standard protocols for imaging and spectroscopy to provide support for researchers at the University of Florida as well as external users through the NSF-funded National High Magnetic Field Laboratory (NHMFL) users program. This position offers unique opportunities to contribute to the development of the MR imaging and spectroscopy program in the AMRIS Facility and the NHMFL and to conduct independent and collaborative research projects. The position will be based in Gainesville, but will involve a close relationship with the NMR Spectroscopy and Imaging Program at the NHMFL in Tallahassee, so occasional travel to that site will be expected. Ongoing research in the Facility includes the application of MR imaging and spectroscopy to biological, biomedical, chemical, and material science research projects and the development of novel imaging and spectroscopy methods. Candidates with an interest in the development of novel methods and/or instrumentation are especially encouraged to apply.

As part of the MR imaging and spectroscopy capabilities, the AMRIS Facility houses the following state-of-the-art MRI/S and NMR systems: a 3 T Phillips Achieva, a 3 T Siemens Prisma, a 4.7 T bore Agilent VNMRS, a 5 T custom DNP polarizer, an 11 T 40 cm Bruker Biospec, an 11.7 5.4 cm Bruker Avance III, a 14.1 T 5.2 cm Bruker Avance III, a 14.1 T 5.4 cm Bruker Avance II, a 14.1 T 5.4 cm Agilent VNMRS and a 17.6 T 8.9 cm Bruker Avance III. A 21 T, 10.4 cm magnet with Bruker Avance system is housed at the NHMFL facility in Tallahassee. The successful candidate will be primarily responsible for MRI/S applications on the vertical bore magnet systems in the AMRIS Facility.

Specific job requirements:

  • Responsible for coordinating, scheduling and ensuring proper utilization of research facilities.
  • Recommend and implement operating policies and procedures in the AMRIS Facility.
  • Keep abreast of current developments and ensure compliance with relevant laws and regulations.
  • Plan and participate in research projects.
  • Help direct and modify research plans.
  • Develop methods and techniques for, and evaluates results of, experiments or studies.
  • Prepare and review manuscripts for publication and presentation at scientific meetings.
  • May serve as liaison between the AMRIS Facility and outside agencies and the general public.

For additional information on the position, please contact Dr. Joanna R. Long, jrlong@ufl.edu, or Dr. Thomas Mareci, thmareci@ufl.edu. The University of Florida is an Equal Opportunity/Access/Affirmative Action Employer. Applications will be accepted October 20-November 19 at http://explore.jobs.ufl.edu/cw/en-us/job/499229/core-research-facility-manager.

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IVAN (International Varian-Agilent NMR users group) Introduction

Introduction of IVAN

The International Varian-Agilent NMR users group sponsored by MR Resources.

MR Resources is pleased to announce the formation of a new international organization directed toward owners and users of NMR spectrometers from Varian Inc. and Agilent Technologies Inc.

As we all know, on October 14, 2014 Agilent Technologies Inc., owner of the former NMR division of Varian Inc., exited the NMR business. As a result, during the two years since, MR Resources has greatly increased its service and support commitment to Varian-Agilent NMR owners and users, welcoming many new customers in the process. MR Resources is fully dedicated to helping support the approximately 5,500 Varian-Agilent NMR spectrometers that remain in use worldwide. We hope that MR Resources will be the new home for all Varian-Agilent NMR spectrometer owners and users worldwide.

As such, to further increase our on-going commitment to Varian-Agilent NMR users, MR Resources will provide full and exclusive sponsorship for the IVAN Users Group. The purpose of the group will be to facilitate on-going technical support of the International Varian-Agilent NMR spectrometer user community by fostering interactive information exchange and face-to-face meetings of users. We wish to provide a much needed home base and platform for meetings, communications and other activities for owners and users of Varian-Agilent NMR spectrometers. MR Resources and IVAN are not affiliated with Agilent Technologies Inc. or Varian Inc. in any way.

The IVAN Users Group is now officially active, and to start things off MR Resources will sponsor a series of informative and interactive meetings for Varian-Agilent NMR users locally, regionally and in conjunction with NMR conferences. The IVAN meetings will take place in different locations around the world. Locations for meetings will be determined by the needs of users. Please indicate on the membership sign-up form if you would like to participate in an organization in your area. These meetings will be exclusive to IVAN User Group members and will be free of charge to attend. These meetings will bring together owners, customers and users, along with MR Resources personnel and many highly committed former Varian-Agilent experts. Indeed, the IVAN Executive Committee is comprised of a \”Who\’s Who\” from the Varian-Agilent NMR companies and the NMR community at large. Our first meeting will be in San Jose, California at the Fairmont Hotel on Friday October 28, 2016. We are also planning a subsequent full day meeting to accompany the Asilomar ENC in the spring of 2017 to be held the Saturday before the ENC opening.

If you are an owner of a Varian-Agilent NMR spectrometer or an interested user, you are invited to join IVAN and attend our meetings, as well as participate in other activities that will soon be developed. Select Join IVAN and fill out the membership form. We urge as many Varian-Agilent NMR spectrometer owners and users worldwide to join this very important group in order to ensure continuing operation and longevity of the Varian-Agilent NMR systems that we all have such a huge investment in.

Membership

Membership in IVAN is available to all Varian-Agilent NMR spectrometer owners and interested users, independent of your service plan or status as a MR Resources customer. There is no charge to become a member or to participate in meetings and activities. There are some restrictions on membership for those who do not identify as a direct Varian-Agilent NMR end-user site and for those that are NMR Vendors. MR Resources intends its own commercial involvement in the user group to be low key. The success of the IVAN user group depends upon the activities of its members. The role of MR Resources is to provide a home for meetings and communication. An email link is available on the membership form to contact us directly with questions about membership.

The on-going objectives for IVAN will be those of its users to enhance the usefulness of their NMR systems, extend the lifetime of the instruments, and to keep them running properly.

First IVAN Meeting, Fall 2016

We invite you to attend a kick-off meeting for IVAN in the San Francisco Bay Area on Friday October 28, 2016. The meeting will be one day – 10:00 AM to 3:30 PM at the Fairmont Hotel in San Jose, including lunch and followed by a \”Happy Hour\” at the Fairmont. Once you join IVAN you may select Our First Meeting in San Jose to register for the upcoming user meeting.

We have a large conference room and catering arranged for up to 100 individuals. Space is limited so sign up early! We hope to see many of you from the Bay Area and we make a special invitation to users from the US West Coast and further distances as well. We promise that you will not be disappointed and hope you can make it if possible! If not, a meeting the day before ENC in Monterey, California is in planning, and other local meetings are already under discussion.


Agenda for the Founding San Jose IVAN Meeting

  9:00 AM:  

Registration and Coffee at the Fairmont

10:00 AM:

Welcome and Introduction of Jon Webb (Dave Rice)

10:10 AM:

A Vision for the Future for Varian-Agilent NMR  (Jon Webb, MR Resources)

10:45 AM: 

Announcing OpenVnmrJ1 Software for the Varian-Agilent Community (Dan Iverson)

11:30 AM:

Discussion Topic:

Moving Forward Together with Service and Applications2 (chair: Michele Bodner)

12:00 PM:

Lunch will be served during the discussion.

1:15 PM 

Operation/Applications Sessions3 (organizers: Krish Krishnamurthy and Dave Russell)

3:00-3:30 PM

Conclusions and Planning for the Future

4:00 PM …. 

 “Happy Hour” (Soda, Wine and Beer Catered)


1OpenVnmrJ1.1A is an open-source successor to Agilent\’s VnmrJ4.2A, released by VOSSG, the VnmrJ Open-Source Steering Committee on 12-Sept-2016. VOSSG will continue development of OpenVnmrJ in association with the IVAN group.

2 A discussion of how we users can enhance the longevity and productivity of our Varian-Agilent consoles, probes and magnets. Bring your questions and issues.

3 We anticipate special topics chosen from the list below. Check the website www.mrr.com for potential topics.


Meeting Special Topics


The topics below are under consideration for the afternoon sessions. Feel free to give your feedback about the choices with the following email link. We will select a subset, but at the very least, experts in these topics will be present at the San Jose meeting. Come with your questions!

  • New Veripulse Calibration with OpenVnmrJ (and VnmrJ4.2)
  • Software Administration and Automation with OpenVnmrJ (and VnmrJ4.2)
  • New 1D and 2D CRAFT from Chempacker
  • Using Chempack Tools
  • Biopack, NUS and NMRPipe with OpenVnmrJ (and VnmrJ4.2)
  • Managing Solids and Programming with SolidsPack Tools.
You can register for IVAN at the MRR webiste here. IVAN Registration

If you have more questions about IVAN you can send us an e-mail thru our website here. IVAN Questions

This email was sent to tmaly@bridge12.com 

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Meet Bridge12 at ENC in Pittsburgh #DNPNMR

Meet Bridge12 at this year\’s ENC in Pittsburgh from April 10th – 15th. This will be the first time that Bridge12 has a small booth, showcasing some of our products.

Thorsten Maly will also give a talk in the DNP Methods & Applications session on Thursday morning from 10:45-12:30pm in Grand 2. He will be presenting our shoebox-sized 263 GHz EPR spectrometer for DNP-NMR.

Hope to see you at ENC and please stop by at our booth to discuss your ideas for DNP-NMR spectroscopy. Our goal is to help you focusing on your research, not trouble-shooting home-built instrumentation.

Meet Bridge12 at the 5th International DNP Symposium

Meet Thorsten Maly from Bridge12 Technologies, Inc. at the 5th International DNP Symposium in Egmond aan Zee (The Netherlands). The symposium will be held starting Monday August 31st and is ending Friday September 4th, 2015.

Dr. Maly will give a talk in the Instrumentation Session on Tuesday (8:30 – 12:30) giving an overview of our current research towards an Integrated Gyrotron System for DNP-NMR Spectroscopy.

Feel free to pull Dr. Maly aside if you would like to discuss your DNP-NMR spectroscopy applications or contact him at tmaly@bridge12.com.

Happy 4th of July

I grew up in Germany and the biggest bummer was when a Holiday fell on a weekend day, because that day off was gone.

Not so in the US. I don\’t know how many other countries follow the same rule but if a Holiday falls on a weekend day you either have the Friday or the Monday off. So day off for me today, and a Happy 4th of July to all my American friends – enjoy the fireworks.

Cheers,
Thorsten

Have a question?

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