Category Archives: Opportunity

Open Position: Junior Scientist – Magnetic Resonance

Bridge12 is hiring.

We are seeking to fill an open position in our team for a Junior Scientist. You will work on multidisciplinary projects covering many different aspects of magnetic resonance, instrumentation design, development of prototypes and conduct research. This is a junior position and while some experience or a background in magnetic resonance spectroscopy (e.g. NMR, EPR, MRI, DNP) is desired, it is not necessary.

We are looking for a creative, highly motivated, highly organized individual who enjoys an innovative, interdisciplinary environment and the challenges that come with manufacturing high-tech, scientific instrumentation. This position requires the ability to apply sound scientific fundamentals to the design and characterization of magnetic resonance instruments.

For more information visit: JUNIOR SCIENTIST – MAGNETIC RESONANCE SPECTROSCOPY

From SharedEPR: New EPR job openings

If you haven’t heard of SharedEPR, check it out here: https://sharedepr.org/

Dear SharedEPR community,

There are a series of current job openings related to EPR spectroscopy. See below. Please forward to potentially interested people.

Facility Manager for the Centre for Pulse EPR Spectroscopy (PEPR) at Imperial College London

https://www.imperial.ac.uk/jobs/description/NAT00757/facility-manager-centre-pulse-epr-spectroscopy-pepr

Closing date: 20 October 2020

Informal enquiries to Dr Maxie Roessler welcome (e-mail m.roessler@imperial.ac.uk)

PhD position (PGR studentship) within the MSCA-ITN-ETN NeuroTrans

Call for application to a PhD position in the field of EPR. Details on the position can be found on https://www.neurotrans.org/projects/project-12-resolving-coarse-grained-dynamic-distance-constraints-of-the-transport-cycle-of-nss-transporters-using-epr-spectroscopy/

Contact: Dr Thomas Stockner, thomas.stockner@meduniwien.ac.at

Closing date: 10 October 2020

Postdoctoral appointee working on transient CW and Pulsed EPR in the Center for Nanoscale Materials and Nanoscience and Technology Division at Argonne National Laboratory

Position is available starting November 2020.

The project aims at investigating the factors influencing spin information and transfer in novel two dimensional structures with well-defined sizes and shapes within supramolecular structures for enhanced emission applications. In these structures, rare earth ions will be caged in well controlled environments consisting of two dimensional networks containing organic linkers whose electronic properties can be tuned by an external stimuli. This electronic tuning will allow the emission of rare earth cations to be turned on or turned off, thereby effectively controlling the optical properties of the supramolecular structure as a whole. This selective adjustment should allow for the potential applications of these structures using rare earth salt mixtures, crude materials of much lower added value than purified rare earth metals. The EPR studies will be complemented with spatially resolved ODMR and synchrotron X-ray STM to understand molecular level of excitations. Depending on the strengths and interests of the successful applicant, the individually designed subproject may be expanded to quantum sensing in nanoscale systems or upconversion nanoparticles. 

We welcome highly motivated candidates with a PhD degree in chemistry or physics. Successful applicants should have a solid background in physical chemistry (spectroscopy), good writing skills and must be able to work independently as part of a team in an interdisciplinary environment. Previous experience in magnetic resonance spectroscopy is required.

For details regarding the application process, salary and possible starting dates please contact Dr. Tijana Rajh (rajh@anl.gov).

Best wishes

The SharedEPR team

[NMR] Postdoctoral Research Staff: Hyperpolarized Imaging

Polarize (www.polarize.dk) was established in 2018 as a startup from the Technical University of Denmark. The company is based in Denmark and has five employees. We manufacture and commercialize the SpinAligner, a pre-clinical polarizer, based on the dissolution-DNP method.

Polarize is seeking to hire a postdoctoral research staff as an on-site scientist at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), to develop hyperpolarized MRI techniques under the supervision of Dr. Yi-Fen Yen and Dr. Jan Henrik Ardenkjaer-Larsen. The successful candidate will operate and maintain a SpinAligner (Polarize, Denmark), develop hyperpolarization technique and MR acquisition methodology for hyperpolarized imaging, and assist collaborators in pre-clinical and translational research.

This work will leverage the state-of-the-art MRI and PET-MRI hardware, and superb expertise in MRI physics, biomedical engineering, radiopharmacy and clinical science at MGH/Martinos. The project will involve hyperpolarized contrast agent development, optimization of MR pulse sequences on Bruker and Siemens scanners, data collection for IND applications, animal and translational hyperpolarized imaging studies for neuroscience, cancer and cardiac research.

The Martinos Center is one of the largest biomedical imaging centers in the United States with over 200 research faculty, post-doctoral fellows and graduate students. This position provides a valuable opportunity to work and collaborate with a multi-disciplinary research team dedicated to developing, validating and translating the latest MRI technology that will benefit the pre-clinical and clinical research communities as well as the diverse patient population served by the MGH.

A Ph.D. (or equivalent) in physics, electrical engineering, biomedical engineering, physical chemistry, or a related field is required; however, strong candidates with other scientific backgrounds will also be considered. The ideal candidate should have a strong analytical background while displaying a high level of creativity. First-hand experience with polarizer operations and in vivo hyperpolarized imaging is a must. Skills in spin physics, hyperpolarization techniques, MRI sequence programming of Bruker and/or Siemens scanners, hyperpolarized contrast agent development, or IND applications are highly desired. Candidates should be highly motivated and interested in working in an interdisciplinary environment with an emphasis on pre-clinical and translational research.

APPLICATION

Interested applicants should send a cover letter describing research experience, interests, and future research and career goals, as well as an up-to-date curriculum vitae and contact information for three references to Yi-Fen Yen, Ph.D., by e-mail: yyen1@mgh.harvard.edu.

Questions regarding this position and informal inquiries should be directed to Yi-Fen Yen, Ph.D., by e-mail: yyen1@mgh.harvard.edu.

The position is full-time with benefits and available starting immediately. A two-year time commitment is required with possibility for extension. Polarize is an Equal Opportunity/Affirmative Action Employer.

Jan Ardenkjaer-Larsen

Managing Director

Email: adm@polarize.dk

Phone: +45 40272775

Homepage: www.polarize.dk

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[NMR] Continuing Search for Research Faculty – 36T SCH Solid-State NMR at NHMFL

Research Faculty – 36T SCH Solid-State NMR

The National High Magnetic Field Laboratory (NHMFL) of the U.S. has an opening for a solid-state NMR Research Faculty position. The primary responsibilities will be developing a research and collaborative user program utilizing the 36 Tesla Series-Connected-Hybrid (SCH), a 12 MWatt powered magnet supporting sub-ppm NMR at 1.5 GHz. Equipped with a custom-made Bruker NEO console, a unique field regulation system and a suite of MAS and oriented sample solid-state NMR probes developed at the NHMFL the 36T SCH magnet provides the highest magnetic field available today capable for high-resolution solid-state NMR of biosolids and materials applications [J. Magn. Reson., 284, 125-136 (2017)]. The Research Faculty will work with a team of engineers and scientists and be responsible for: (1) developing a research program in biosolids and in materials applications with quadrupolar and spin-1/2 nuclei utilizing the high-field magnets at the NHMFL; (2) supporting the 36T SCH user program, that includes NMR system management, project initiation, planning and execution with users. This Faculty is expected to be a motivated researcher with excellent communication skills, a collegial personality, a team-player, and a scientist with the vision to become a world-class researcher. 

The NHMFL’s NMR/MRI user program operates a state-of-the-art user facility at the Magnet Lab conducting research at the frontiers of physics, chemistry, biology, material sciences with unique magnet technologies. It has an outstanding infrastructure with an array of NMR spectrometers including 900MHz, 830MHz, three 800MHz, 600MHz MASDNP, four 600MHz and other lower field instruments. The candidate will have support from a team of engineers and scientists, for the 36T SCH, in particular, and opportunities to collaborate with national and international users, to apply for grants, to publish and to pursue individual research objectives, as well as to participate in national and international organizations and conferences.

Qualifications include a Ph.D. in chemistry, biochemistry, biophysics, physics or materials sciences with research experience focused on solid-state NMR. Candidates should have excellent experimental NMR skills including spectrometer operations, data processing, pulse-sequence development and implementation, as well as being knowledgeable in NMR instrumentation and probe hardware. The candidate is expected to have excellent writing skills, a strong track record in publications, and experience working in a multidisciplinary research environment.

Applications and inquiries can be sent to: Zhehong Gan, Search Chair, SCH NMR Research Faculty, gan@magnet.fsu.edu at this moment. Please attach your curriculum vitae, and a cover letter describing your research experience and interest in the position.

Formal applications will need to be submitted after the COVID19 application and travel restrictions are lifted; this application will be made to Florida State University at https://jobs.fsu.edu (reference Job ID #46306). For additional information, please contact Ms. Bettina Roberson, National High Magnetic Field Laboratory, Florida State University, 1800 E. Paul Dirac Drive, Tallahassee, FL 32310-2740, roberson@magnet.fsu.edu, 850-644-0855.

Zhehong Gan 

National High Magnetic Field Laboratory (NHMFL) 

1800 East, Paul Dirac Drive, 

Tallahassee, FL 32310

email: gan@magnet.fsu.edu

phone: 850-644-4662, fax: 850-644-1366

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Bridge12 is looking for a Mechanical Engineer #Bridge12

Bridge12 has an opening for a mechanical engineer.

As a Mechanical Engineer at Bridge12, you will work on multidisciplinary projects that involve the development of microwave and terahertz generators, particle accelerators and other scientific instrumentation. There will be occasional travel associated with installation and testing at a customer site or visiting vendors.

For more information visit:

http://www.bridge12.com/mechanical-engineer/

[NMR] PhD position with NV centres in diamond at the Helmholtz Zentrum Berlin

Dear colleagues and friends,

we are searching for a highly motivated PhD candidate within the DFG funded project “Quantum many body interactions in a two dimensional solid state system”. The goal is to create and use single spins in diamond (nitrogen vacancy centres, shortly NV) to control nanoscale two dimensional (2D) arrays of nuclear spins, with the final goal being the realisation of a solid state quantum simulator.

The description of the position and a link for application can be found here:

https://recruitingapp-5181.de.umantis.com/Vacancies/1131/Description/2?lang=eng

For further information feel free to contact me.

I would be very grateful if you could distribute this email to any suitable candidates of whom you are aware.

Thank you very much!

Best wishes,

Boris Naydenov

Dr. Boris Naydenov

Helmholtz-Zentrum Berlin für Materialien und Energie (HZB)

Institute for Nanospectroscopy

Kekuléstraße. 5

D-12489 Berlin

Germany

Telefon:

+49 30 8062 – 41373

________________________________

Helmholtz-Zentrum Berlin für Materialien und Energie GmbH

Mitglied der Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren e.V.

Aufsichtsrat: Vorsitzender Dr. Volkmar Dietz, stv. Vorsitzende Dr. Jutta Koch-Unterseher

Geschäftsführung: Prof. Dr. Bernd Rech (Sprecher), Prof. Dr. Jan Lüning, Thomas Frederking

Sitz Berlin, AG Charlottenburg, 89 HRB 5583

Postadresse:

Hahn-Meitner-Platz 1

D-14109 Berlin

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[NMR] ERC-funded PhD positions in small-molecule NMR – Nantes, France #DNPNMR

Dear colleagues,

Three ERC-funded PhD positions are open in the Nantes NMR group of the CEISAM research institute, in the field of small-molecule NMR of complex mixtures.

The PhD students will join a dynamic NMR group and work on two ERC-funded projects led by Jean-Nicolas Dumez and Patrick Giraudeau. The three PhD projects will consist of:

1) developing methods for fast diffusion-ordered NMR spectroscopy (DOSY), based on the principles of spatial encoding (SPEN), for the monitoring of out-of-equilibrium systems. These methods will be applied to reaction monitoring on a variety of chemical systems.

2) developing ultrafast 2D NMR heteronuclear methods for the analysis of complex biological samples hyperpolarized by dissolution dynamic nuclear polarization. The methods will be applied to various research questions in the field of metabolomics.

3) developing a variety of homo- and hetero-nuclear NMR methods for the analysis of out-of-equilibrium complex mixtures involving flow analysis and/or hyperpolarization.

Applicants should have a background in chemistry (preferentially analytical or physical) or physics, and a strong interest in both fundamental and applied aspects of magnetic resonance.

The NMR group of the CEISAM lab works on method developments in solution-state NMR and their application to the analysis of mixtures. It is equipped with state-of-the-art NMR spectrometers, in the 400 to 700 MHz range, a microimaging system and a prototype polariser for dissolution-DNP. CEISAM is the molecular chemistry lab of the Université de Nantes, where research includes physical and analytical chemistry, organic synthesis and catalysis, and chemical biology. The lab is located in the vibrant city of Nantes, close to the Atlantic Coast of south Brittany.

Positions are for three years and will start on October 1st 2020. Please send applications including cover letter, CV and the name of two referees to Jean-Nicolas Dumez and Patrick Giraudeau. The first round of applications will be closed on March 31st.

Please forward this message to potential candidates.

Best regards

Jean-Nicolas Dumez and Patrick Giraudeau

Prof. Patrick GIRAUDEAU

CEISAM/Chemistry Department

Faculty of Science and Technology

Tel : (33)251125709

Mail: patrick.giraudeau@univ-nantes.fr

2 rue de la Houssinière BP 92208

44322 Nantes Cedex 3

FRANCE

Website: www.univ-nantes.fr/giraudeau-p

Be eco-friendly: print this e-mail only if necessary

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Postdoctoral Position: EPR Spectroscopic Studies of Membrane Proteins #EPR

Postdoctoral Position: EPR Spectroscopic Studies of Membrane Proteins

Miami University, Oxford, OH, USA

A Postdoctoral research position is available immediately to study the structural and dynamic properties of integral membrane proteins in the laboratory of Prof. Gary A. Lorigan in the Department of Chemistry and Biochemistry at Miami University in Ohio. The postdoctoral position is funded through a NIH MIRA R35 grant.

Candidates who are interested in studying the structural and dynamic properties of membrane proteins are encouraged to apply. Experience in two of the following areas is desirable: molecular biology and biochemistry of membrane proteins, protein purification, and EPR spectroscopy. 2 pulsed EPR spectrometers (X-band/Q-band) for DEER and ESEEM experiments, 2 CW-EPR spectrometers, and a 500 MHz solid-state NMR instrument are available for this project. Miami University is home to the Ohio Advanced EPR Lab (http://epr.miamioh.edu). Please send a CV and two letters of recommendation to: Professor Gary A. Lorigan, Department of Chemistry and Biochemistry, Miami University gary.lorigan@miamioh.edu. A Ph.D. in Chemistry/Biochemistry or related fields is required. Contact phone is 513-529-3338. 

Miami University, an Equal Opportunity/Affirmative Action employer, encourages applications from minorities, women, protected veterans and individuals with disabilities. Miami University prohibits harassment, discrimination and retaliation on the basis of sex/gender (including sexual harassment, sexual violence, sexual misconduct, domestic violence, dating violence, or stalking), race, color, religion, national origin (ancestry), disability, age (40 years or older), sexual orientation, gender identity, pregnancy, status as a parent or foster parent, military status, or veteran status in its recruitment, selection, and employment practices. Requests for all reasonable accommodations for disabilities related to employment should be directed to ADAFacultyStaff@miamioh.edu or 513-529-3560.

As part of the University’s commitment to maintaining a healthy and safe living, learning, and working environment, we encourage you to read Miami University’s Annual Security & Fire Safety Report at http://www.MiamiOH.edu/campus-safety/annual-report/index.html(http://www.miamioh.edu/campus-safety/annual-report/index.html), which contains information about campus safety, crime statistics, and our drug and alcohol abuse and prevention program designed to prevent the unlawful possession, use, and distribution of drugs and alcohol on campus and at university events and activities. This report also contains information on programs and policies designed to prevent and address sexual violence, domestic violence, dating violence, and stalking. Each year, email notification of this website is made to all faculty, staff, and enrolled students. Written notification is also provided to prospective students and employees. Hard copies of the Annual Security & Fire Safety Report may be obtained from the Miami University Police Department at (513) 529-2225.

Gary A. Lorigan

John W. Steube Professor 

Department of Chemistry and Biochemistry

Miami University

651 E. High St.

Oxford, Ohio 45056

Office: 137 Hughes Laboratories

Phone: (513) 529-3338

Fax: (513) 529-5715

e-mail: gary.lorigan@miamioh.edu

web: www.users.muohio.edu/lorigag/index.html

EPR facility: epr.muohio.edu

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Postdoctoral position: DNP-enhanced biomolecular solid-state NMR-spectroscopy for the study of protein (mis)folding #DNPNMR

A postdoctoral position is available in the group of Henrike Heise at Forschungszentrum Juelich/Heinrich Heine University Duesseldorf

The successful candidate will study disordered and aggregation-prone proteins in all stages of the misfolding pathway. Further, interaction with potential drug candidates will be elucidated. State-of-the art solid-state NMR-spectroscopy, involvng polarization enhancement by DNP and fast magic angle spinning will be applied to elucidate those processes at atomic resolution. A selection of relevant publication is given below.

Our laboratory at the Forschungszentrum Jülich is equipped with state of the art solid-state NMR spectrometers operating at 800 and 600 MHz, DNP equipment is available for 600 and 800 MHz spectrometers. An ultrafast MAS probe head for spinning speeds up to > 100 kHz will be available soon, the installation of an ultrahigh field spectrometer operating at 1.2 GHz is scheduled for 2020.

The Forschungszentrum Jülich offers a vibrant research environment with close collaborations with the University of Düsseldorf, the RWTH Aachen University and the Max-Planck Institute Mülheim. Our laboratory is part of the Jülich center of structural biology JuStruct which bundles expertise with infrastructure in the field of atomic resolution of structural biology (NMR in solution and the solid state, X-ray crystallography,cryo-EM, molecular modelling and neutron scattering).

The initial appointment is for a year, with a possibility of renewal.The initial appointment is for a year, with a possibility of renewal.

Applications will be reviewed on a rolling basis, and candidates will be considered until the position is filled.

The ideal candidate should have a strong background in biomolecular NMR-spectroscopy. Experience with hyperpolarization and/ or Protein expression and purfication is a plus. Applicants must submit a cover letter summarizing research experience and specifying the interests in this position; a curriculum vitae (including a publication list); a statement of research interests; and two letters of reference to henrike.heise@hhu.de

Information about our group:

http://www.fknmr.hhu.de/en/

Selection of relevant publications:

  • L. Siemons, B. Uluca-Yazgi, R. B. Pritchard, S. McCarthy, H. Heise, D. F. Hansen, Determining isoleucine side-chain rotamer-sampling in proteins from 13C chemical shift, Chem.Commun. 2019, in press. doi:10.1039/C9CC06496F.
  • A. König, D. Schölzel, B. Uluca, T. Viennet, Ü. Akbey, H. Heise, Hyperpolarized MAS NMR of unfolded and misfolded proteins, Solid State NMR, 2019, 98, 1-11.
  • B. Uluca, T. Viennet, D. Petrović, H. Shaykhalishahi, F. Weirich, A. Gönülalan, B. Strodel, M. Etzkorn, W. Hoyer, and H. Heise. DNP-Enhanced solid-state NMR at Cryogenic Temperatures: a Tool to Snapshot Conformational Ensembles of α-Synuclein in Different States. Biophys. J. 2018, 114, 1614-1623.
  • L. Gremer, D. Schölzel, C. Schenk, E. Reinartz, J. Labahn, R. Ravelli, M. Tusche, C. Lopez-Iglesias, W. Hoyer, H. Heise, D. Willbold, G. Schröder, Fibril structure of amyloid-ß(1-42) by cryo-electron microscopy, Science, 2017, 358, 116-119.
  • T. Viennet, A. Viegas, A. Kuepper, S. Arens, V. Gelev, O. Petrov, T. N. Grossmann, H. Heise, M. Etzkorn, Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization. Angew. Chem. Int. Ed. Engl. 2016, 55, 10746-10750.

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Forschungszentrum Juelich GmbH

52425 Juelich

Sitz der Gesellschaft: Juelich

Eingetragen im Handelsregister des Amtsgerichts Dueren Nr. HR B 3498

Vorsitzender des Aufsichtsrats: MinDir Volker Rieke

Geschaeftsfuehrung: Prof. Dr.-Ing. Wolfgang Marquardt (Vorsitzender),

Karsten Beneke (stellv. Vorsitzender), Prof. Dr.-Ing. Harald Bolt,

Prof. Dr. Sebastian M. Schmidt

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[NMR] PhD scholarship in Hyperpolarization of Water for Angiography and Perfusion #DNPNMR

We have an open position as PhD student.

Application deadline is soon: Nov 15, 2019!

The PhD project is part of a EU FET Open funded consortium targeting alternatives to conventional Gadolinium based MR contrast agents for angiography and perfusion imaging. The consortium pursues several approaches, but this PhD project specifically aims to develop and study hyperpolarized water by dissolution Dynamic Nuclear Polarization for perfusion and angiography. Hyperpolarized water can provide a signal that is several orders of magnitude stronger than the tissue signal, and could enable superior angiograph and perfusion imaging. The key idea in the project is to study formulations of the hyperpolarized water that can extend the relaxation time of the water protons after injection into the blood stream, e.g. through micro-emulsions. This would shift hyperpolarized water from being an invasive, intra-arterial method to becoming equivalent in use to conventional MR contrast agents as a non-invasive, intravenous agent.

Online application at: https://www.dtu.dk/Om-DTU/Job-og-karriere/Ledige-stillinger/job?id=03a3248e-556b-47de-bfe0-92ac0c9906f0

Best regards, Jan

Jan Henrik Ardenkjær-Larsen

Professor and Section Head

Center for Magnetic Resonance

Technical University of Denmark 

Department of Health Technology

Ørsted Plads, bldg 349, office 126

DK – 2800 Kgs. Lyngby

Phone +45 45253918

Mobile +45 40272775

jhar@elektro.dtu.dk

hypermag.dtu.dk

cmr.elektro.dtu.dk

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