Category Archives: Open Position

[NMR] PhD and postdoc positions at MPI Göttingen

Dear colleagues, I have three position to fill in my group at the Max Planck Institute for Biophysical Chemistry in Göttingen. Please see the postings below and feel free to forward this mail to interested candidates.
Best regards,

Stefan Glöggler
Max Planck Institute for Biophysical Chemistry
NMR Signal Enhancement
Dr. Stefan Glöggler
Am Fassberg 11
37077 Göttingen, Germany
https://www.mpibpc.mpg.de/gloeggler

Open positions:

Postdoc for hyperpolarized in vivo magnetic resonance imaging (preclinical):We are looking for a highly motivated postdoc with experience in preclinical hyperpolarized magnetic resonance in vivo who wants to work in a multidisciplinary team on magnetic resonance spectroscopy and imaging of metabolism in the brain. The successful candidate will benefit from state-of-the-art high field NMR and microimaging equipment and a team of chemists dedicated to develop new hyperpolarized contrast agents.Your Profile

  • A completed PhD and training in hyperpolarized in vivo magnetic resonance
  • A minimum of three years experience with preclinical in vivo experiments
    (please provide evidence and certificates with your application)
  • Independent thinking, structured work organization and a good team spirit are expected
  • Postdocs hold a PhD or equivalent degree

Additional InformationThe position will be open until filled with the earliest possible starting date of January 1, 2021.The payment and benefits are based on the TVöD guidelines.The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.Please submit your application including a cover letter (explaining background and motivation), your CV, complete transcripts and two letters of recommendation send under separate cover preferably via e-mail as a single PDF file with the subject “In vivo” to
ausschreibung22-20@mpibpc.mpg.de

Postdoc or PhD student for in-cell NMR:We are looking for a highly motivated biochemist/biologist with a strong background in NMR who wants to work in a multidisciplinary team on aspects of protein aggregation related to neurodegeneration, cell metabolism and hyperpolarization. The successful candidate will benefit from state-of-the-art high field NMR equipment including a 900 MHz, 950 MHz and the recently installed 1.2 GHz spectrometer.Your Profile

  • Excellent degree in biochemistry, biology or a related discipline
  • Experience/Interest in NMR and structural biology
  • Knowledge and hands-on experience with cell culture
  • Independent thinking, structured work organization and a good team spirit are expected
  • PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree

Additional InformationThe position will be open until filled with the earliest possible starting date of January 1, 2021. The PhD position is limited to four years with a possibility of extension.The payment and benefits are based on the TVöD guidelines.The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.Please submit your application including a cover letter (explaining background and motivation), your CV, complete transcripts and two letters of recommendation send under separate cover preferably via e-mail as a single PDF file with the subject “In-Cell” to
ausschreibung21-20@mpibpc.mpg.de

Postdoc or PhD student for singlet state magnetic resonance:We are looking for a highly motivated physicist/physical chemist/biophysicist with experience/interest in NMR and pulse sequence development who wants to work in a multidisciplinary team on magnetic resonance spectroscopy and imaging, metabolism research and hyperpolarization. The successful candidate will benefit from state-of-the-art high field NMR and microimaging equipment.Your Profile

  • Excellent degree in physics, physical chemistry, biophysics or related disciplines
  • Experience/interest in NMR and in pulse sequence development
  • Independent thinking, structured work organization and a good team spirit are expected
  • PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree

Additional InformationThe position will be open until filled with the earliest possible starting date of January 1, 2021. The PhD position is limited to four years with a possibility of extensionThe payment and benefits are based on the TVöD guidelines.The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.Please submit your application including a cover letter (explaining background and motivation), your CV, complete transcripts and two letters of recommendation send under separate cover preferably via e-mail as a single PDF file with the subject “Singlet” to
ausschreibung23-20@mpibpc.mpg.de


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[NMR] Postdoc position in NMR/DNP of heterogeneous catalysts at

Dear Colleagues,

We are seeking a postdoctoral associate with a background in solid-state NMR spectroscopy for the solid-state NMR investigations of heterogeneous catalysts, by conventional as well as dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy. A significant portion of the work will involve solid-state NMR methods development for instance through the development of novel data analysis tools, pulse sequence development, and the advancement and application of emerging technologies including ultra-fast (100 kHz+) magic-angle-spinning, dynamic nuclear polarization, and ultrahigh magnetic fields. The main focus of the work will be geared towards gaining a dynamic understanding of the structures of heterogeneous catalyst surfaces through multidimensional NMR spectroscopy.

Ames Laboratory is equipped with 9.4 and 14.1 T solid-state NMR spectrometers with MAS probes for rotor diameters ranging from 5 to 0.7-mm. Aside from these instruments, the lab is also equipped with a 9.4 T Bruker MAS-DNP NMR spectrometer with both 3.2 and 1.3-mm MAS-DNP probes. Access to computational resources and synthetic resources will also be available.

Interested people are encouraged to apply for the position. More details can be found at this link:

https://isu.wd1.myworkdayjobs.com/en-US/IowaStateJobs/job/Ames-IA/Postdoctoral-Research-Associate—Ames-Laboratory_R2763

Best,

Frédéric Perras, PhD

Ames Laboratory

US Department of Energy

Ames, IA, 50011

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Open Position: Junior Scientist – Magnetic Resonance

Bridge12 is hiring.

We are seeking to fill an open position in our team for a Junior Scientist. You will work on multidisciplinary projects covering many different aspects of magnetic resonance, instrumentation design, development of prototypes and conduct research. This is a junior position and while some experience or a background in magnetic resonance spectroscopy (e.g. NMR, EPR, MRI, DNP) is desired, it is not necessary.

We are looking for a creative, highly motivated, highly organized individual who enjoys an innovative, interdisciplinary environment and the challenges that come with manufacturing high-tech, scientific instrumentation. This position requires the ability to apply sound scientific fundamentals to the design and characterization of magnetic resonance instruments.

For more information visit: JUNIOR SCIENTIST – MAGNETIC RESONANCE SPECTROSCOPY

[NMR] Postdoctoral Research Staff: Hyperpolarized Imaging

Polarize (www.polarize.dk) was established in 2018 as a startup from the Technical University of Denmark. The company is based in Denmark and has five employees. We manufacture and commercialize the SpinAligner, a pre-clinical polarizer, based on the dissolution-DNP method.

Polarize is seeking to hire a postdoctoral research staff as an on-site scientist at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), to develop hyperpolarized MRI techniques under the supervision of Dr. Yi-Fen Yen and Dr. Jan Henrik Ardenkjaer-Larsen. The successful candidate will operate and maintain a SpinAligner (Polarize, Denmark), develop hyperpolarization technique and MR acquisition methodology for hyperpolarized imaging, and assist collaborators in pre-clinical and translational research.

This work will leverage the state-of-the-art MRI and PET-MRI hardware, and superb expertise in MRI physics, biomedical engineering, radiopharmacy and clinical science at MGH/Martinos. The project will involve hyperpolarized contrast agent development, optimization of MR pulse sequences on Bruker and Siemens scanners, data collection for IND applications, animal and translational hyperpolarized imaging studies for neuroscience, cancer and cardiac research.

The Martinos Center is one of the largest biomedical imaging centers in the United States with over 200 research faculty, post-doctoral fellows and graduate students. This position provides a valuable opportunity to work and collaborate with a multi-disciplinary research team dedicated to developing, validating and translating the latest MRI technology that will benefit the pre-clinical and clinical research communities as well as the diverse patient population served by the MGH.

A Ph.D. (or equivalent) in physics, electrical engineering, biomedical engineering, physical chemistry, or a related field is required; however, strong candidates with other scientific backgrounds will also be considered. The ideal candidate should have a strong analytical background while displaying a high level of creativity. First-hand experience with polarizer operations and in vivo hyperpolarized imaging is a must. Skills in spin physics, hyperpolarization techniques, MRI sequence programming of Bruker and/or Siemens scanners, hyperpolarized contrast agent development, or IND applications are highly desired. Candidates should be highly motivated and interested in working in an interdisciplinary environment with an emphasis on pre-clinical and translational research.

APPLICATION

Interested applicants should send a cover letter describing research experience, interests, and future research and career goals, as well as an up-to-date curriculum vitae and contact information for three references to Yi-Fen Yen, Ph.D., by e-mail: yyen1@mgh.harvard.edu.

Questions regarding this position and informal inquiries should be directed to Yi-Fen Yen, Ph.D., by e-mail: yyen1@mgh.harvard.edu.

The position is full-time with benefits and available starting immediately. A two-year time commitment is required with possibility for extension. Polarize is an Equal Opportunity/Affirmative Action Employer.

Jan Ardenkjaer-Larsen

Managing Director

Email: adm@polarize.dk

Phone: +45 40272775

Homepage: www.polarize.dk

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[NMR] NMR facility position available

Dear colleagues:

UC Irvine is looking for a Biomolecular NMR Spectroscopy Manager to oversee the BioMolecular Spectroscopy Facility in the Department of Chemistry. The position is responsible for the technical and administrative needs of the facility. The manager solves structures using NMR analysis, maintains equipment, facilitates billing, collaborates with faculty on applications of NMR in their research, and contributes to faculty research initiatives.

Interested parties should apply at: https://careersucirvine.ttcportals.com/jobs/5388243-assistant-development-engineer. The search has an initial close date of 9/14/20 and may be extended if necessary.

Please feel free to contact me (rwmartin@uci.edu) with questions.

Best,
Rachel

Rachel W. Martin
Professor of Chemistry
and Molecular Biology & Biochemistry
University of California, Irvine
rwmartin@uci.edu
probemonkey.com

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[NMR] Permanent position for a researcher – staff scientist at CEA Grenoble in DNP-enhanced solid-state NMR #DNPNMR

Permanent position opening for a researcher – staff scientist at CEA Grenoble In the field of DNP-enhanced solid-state NMR

Job description

The Interdisciplinary Research Institute of Grenoble (IRIG) has an open position for a researcher – staff scientist specialist in NMR spectroscopy applied to the chemical sciences. The successful candidate will be affiliated to the Modeling and Exploration of Materials Laboratory (MEM), a joint research unit of CEA and the University Grenoble Alpes. He/she will join the DNP research group led by G. De Paëpe at the IRIG, CEA Grenoble, France.

The successful candidate will participate in the research activities of the group, will build and manage new projects with academic and industrial partners. He/She will also be in charge of the DNP-NMR lab equipment in terms of day-to-day operation, maintenance, hardware troubleshooting and fixing. As such, duties include operation of 2 high-field DNP-NMR spectrometers, a fully automated cryostat for close-loop cryogenic helium sample spinning, developing and testing helium/nitrogen fast MAS DNP probes. A central aspect of the work will consist in setting up established pulse sequences (for spin ½ and quadrupolar nuclei) but also to design and develop innovative sequences, data acquisition and processing protocols, as well as user-friendly post-processing analysis tools. The position implies as well, taking an active part in training and guiding graduate students from the group.

Scientific environment and workplace

The MEM laboratory currently hosts 2 DNP spectrometers, including the first DNP spectrometer installed in France (2011). Since then, the laboratory has gained international recognition in the DNP field. The originality of the Grenoble DNP team lies in the diversity of its research, which encompasses methodological developments (pulse sequences, sample preparation, DNP theory, design of improved polarizing agents, targeted and selective DNP), major instrumental developments (autonomous helium cryostat and fast MAS cryogenic probes operating at very low temperatures << 100 K and fast MAS), but also advanced applications in the field of functional materials and complex biomolecular systems.

The MEM laboratory also hosts 3 other NMR spectrometers (200 / 400 / 500 MHz) equipped with solution, PFG, HRMAS and solid-state NMR probes, including a fast MAS probe and an in operando probe for low field paramagnetic NMR. IRIG gathers 10 laboratories including MEM, with about 1000 researchers, technicians, doctoral and post-doctoral students, covering a large variety of interdisciplinary fields (nanophysics, chemistry for health and energy, cryo-technologies, biology and medicine). Besides, IRIG includes also the IBS NMR groups which are specialized in structural biology and host 6 other NMR instruments (including a 950 MHz spectrometer). This strong environment in NMR is ideally complemented by research teams specialized in EPR, advanced electron microscopy, X-ray (lab equipment and ESRF) and neutron (ILL) diffraction.

Located in the French Alps and surrounded by a stunning natural environment, the international city of Grenoble represents an extremely rich ecosystem formed by public research organizations (CEA, CNRS, ESRF, ILL) and high-tech companies. In addition, the Université Grenoble Alpes attracts a large number of students who can benefit from high-level academic training in a broad range of disciplines.

Qualifications

Candidates should have a PhD in Chemistry / Physical Chemistry / Physics or Engineering with a dissertation awarded from a research group specialized in advanced NMR spectroscopy techniques. The candidate should have hands-on experience in solid-state NMR and dynamic nuclear polarization. Preference will be given to candidates with postdoctoral experience of at least two to three years. The candidate should master NMR acquisition software and have a strong expertise in NMR theory, pulse sequence development and computational analysis. Experience with spectrometer and probe troubleshooting, matlab or equivalent, python scripting etc. is a plus. Excellent communication skills in English and ability to work in a research team is a requirement.

How to Apply

Candidates are requested to send by email a motivation letter and a detailed CV to Gaël De Paëpe at gael.depaepe@cea.fr, deadline for application: August 15th, 2020. Selected candidates will be informed quickly and called for an interview planned in September 2020. Depending on the situation, interviews might be conducted online.

Additional information: This offer corresponds to a tenured position at the French Atomic and Alternative Energy Commission (CEA, www.cea.fr). Salary is commensurate with experience. 

— Dr Gaël De Paëpe CEA / Univ. Grenoble Alpes DRF/IRIG/MEM/RM email gael.depaepe@cea.frvoice (office) +33 4 38 78 65 70 voice (lab) +33 4 38 78 47 26 fax +33 4 38 78 50 90 Mailing address: CEA Grenoble 17 Avenue des Martyrs Bâtiment 51C Office P.132a / Lab P.138 38054 Grenoble Cedex 9 – France 

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[NMR] RF instrumentation position at NHMFL

RF instrumentation position is open at National High Magnetic Field Laboratory in Tallahassee, Florida, funded by a P41 grant from National Institutes of Health:

Responsibilities include carrying out engineering, R&D and operational tasks associated with high field NMR magnet systems, NMR spectrometers, radio-frequency NMR probes and associated technologies. Responsibilities include supporting the development of new capabilities for chemical and biological NMR in resistive, hybrid and superconducting magnets in the NHMFL user facility. The employee will provide instrumentation support to users on high-field NMR systems. Will participate in design and construction of the high-field solid state NMR probes. The employee will work with magnet designers and other technical staff members to refine the homogeneity and regulation of magnetic fields in high-field magnets. The successful applicant will work on a variety of R&D and engineering activities associated with the development of new NMR research facilities.

Seeking candidates who are motivated and eager to work flexibly and creatively in a cross-disciplinary team environment. Good communications skills and the ability to interact constructively with physicists, chemists, engineers, designers, technicians and procurement personnel Experience working with NMR spectrometers, NMR probes and RF amplifiers. Familiar with RF measurement tools including, but not limited to use of a Vector Network Analyzer. Experience with RF circuit design modeling software. Experience with EM field simulation software. Experience with CAD software for mechanical design. Familiarity with NMR principles and experimental methods.

Qualifications: Ph.D. in Electrical Engineering, Physics, Chemistry, or in a closely related field; or an M.S. with at least two years post-graduate experience.

For inquiries, please contact Peter Gor’kov (pgorkov@magnet.fsu.edu). For a complete position description please go to https://hr.fsu.edu/index.cfm?page=ers/ers_home then click “Job Opportunities” and search for “47127” (a job ID). To apply for this position please click “Apply for Job” button on the job description page.

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[NMR] Post-doctoral position in CEA/Saclay

CEA, CNRS, Paris-Saclay University, France

A Postdoctoral research position is available from April 2020 to develop liquid-state NMR methods and instrumentation for sensitive real-time detection of synthesis intermediates. The efficient, rapid and quantitative detection of reaction intermediates by NMR requires that the detection zone be as close as possible to the synthesis reactor. This implies new developments in instrumentation and NMR methods.

The postdoctoral position is funded through an ANR project grant for a period of 12 months. Experience in two of the following areas is desirable: NMR methodology, NMR instrumentation, chemical engineering, 3D-printing. A benchtop NMR spectrometer (43 MHz), two 500 MHz narrow-bore spectrometers and a 300 MHz superwide-bore spectrometer/imager are available in the laboratory for this project. Also, the candidate will have access to the French high-field NMR facility (IR-RMN-THC).

CEA is a major French player in research, development and innovation. The Paris-Saclay cluster, situated 25 km in the south-west of Paris, is a concentration of large groups and innovative SMEs associated with a world-class university center. Being one of the 8 most important innovation centers in the world, Paris-Saclay already accounts for 15% of French public and private research.

Candidates who are interested in participating to this project common to the company CortecNet and the CEA (LSDRM) are encouraged to apply by sending their CV and letters of recommendation to Dr. Patrick Berthault, NIMBE, UMR CEA/CNRS 3685, CEA Saclay, PC #9, F-91191 Gif sur Yvette, France patrick.berthault@cea.fr.

More details on the developments at the origin of this project can be found in these refs:

[1] G. Carret, T. Berthelot, et P. Berthault, « Enhancing NMR of Nonrelaxing Species Using a Controlled Flow Motion and a Miniaturized Circuit », Anal. Chem., vol. 89, p. 2995‑3000, mars 2017. DOI: 10.1021/acs.analchem.6b04488

[2] G. Carret, T. Berthelot, et P. Berthault, « Inductive Coupling and Flow for Increased NMR Sensitivity », Anal. Chem., vol. 90, p. 11169‑11173, oct. 2018. DOI: 10.1021/acs.analchem.8b01775

Patrick Berthault

NIMBE, UMR CEA/CNRS 3685

CEA Saclay

PC #9

F-91191 Gif sur Yvette

France

Tel: +33 1 69 08 42 45

http://iramis.cea.fr/Pisp/patrick.berthault/

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Postdoctoral position: DNP-enhanced biomolecular solid-state NMR-spectroscopy for the study of protein (mis)folding #DNPNMR

A postdoctoral position is available in the group of Henrike Heise at Forschungszentrum Juelich/Heinrich Heine University Duesseldorf

The successful candidate will study disordered and aggregation-prone proteins in all stages of the misfolding pathway. Further, interaction with potential drug candidates will be elucidated. State-of-the art solid-state NMR-spectroscopy, involvng polarization enhancement by DNP and fast magic angle spinning will be applied to elucidate those processes at atomic resolution. A selection of relevant publication is given below.

Our laboratory at the Forschungszentrum Jülich is equipped with state of the art solid-state NMR spectrometers operating at 800 and 600 MHz, DNP equipment is available for 600 and 800 MHz spectrometers. An ultrafast MAS probe head for spinning speeds up to > 100 kHz will be available soon, the installation of an ultrahigh field spectrometer operating at 1.2 GHz is scheduled for 2020.

The Forschungszentrum Jülich offers a vibrant research environment with close collaborations with the University of Düsseldorf, the RWTH Aachen University and the Max-Planck Institute Mülheim. Our laboratory is part of the Jülich center of structural biology JuStruct which bundles expertise with infrastructure in the field of atomic resolution of structural biology (NMR in solution and the solid state, X-ray crystallography,cryo-EM, molecular modelling and neutron scattering).

The initial appointment is for a year, with a possibility of renewal.The initial appointment is for a year, with a possibility of renewal.

Applications will be reviewed on a rolling basis, and candidates will be considered until the position is filled.

The ideal candidate should have a strong background in biomolecular NMR-spectroscopy. Experience with hyperpolarization and/ or Protein expression and purfication is a plus. Applicants must submit a cover letter summarizing research experience and specifying the interests in this position; a curriculum vitae (including a publication list); a statement of research interests; and two letters of reference to henrike.heise@hhu.de

Information about our group:

http://www.fknmr.hhu.de/en/

Selection of relevant publications:

  • L. Siemons, B. Uluca-Yazgi, R. B. Pritchard, S. McCarthy, H. Heise, D. F. Hansen, Determining isoleucine side-chain rotamer-sampling in proteins from 13C chemical shift, Chem.Commun. 2019, in press. doi:10.1039/C9CC06496F.
  • A. König, D. Schölzel, B. Uluca, T. Viennet, Ü. Akbey, H. Heise, Hyperpolarized MAS NMR of unfolded and misfolded proteins, Solid State NMR, 2019, 98, 1-11.
  • B. Uluca, T. Viennet, D. Petrović, H. Shaykhalishahi, F. Weirich, A. Gönülalan, B. Strodel, M. Etzkorn, W. Hoyer, and H. Heise. DNP-Enhanced solid-state NMR at Cryogenic Temperatures: a Tool to Snapshot Conformational Ensembles of α-Synuclein in Different States. Biophys. J. 2018, 114, 1614-1623.
  • L. Gremer, D. Schölzel, C. Schenk, E. Reinartz, J. Labahn, R. Ravelli, M. Tusche, C. Lopez-Iglesias, W. Hoyer, H. Heise, D. Willbold, G. Schröder, Fibril structure of amyloid-ß(1-42) by cryo-electron microscopy, Science, 2017, 358, 116-119.
  • T. Viennet, A. Viegas, A. Kuepper, S. Arens, V. Gelev, O. Petrov, T. N. Grossmann, H. Heise, M. Etzkorn, Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization. Angew. Chem. Int. Ed. Engl. 2016, 55, 10746-10750.

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Forschungszentrum Juelich GmbH

52425 Juelich

Sitz der Gesellschaft: Juelich

Eingetragen im Handelsregister des Amtsgerichts Dueren Nr. HR B 3498

Vorsitzender des Aufsichtsrats: MinDir Volker Rieke

Geschaeftsfuehrung: Prof. Dr.-Ing. Wolfgang Marquardt (Vorsitzender),

Karsten Beneke (stellv. Vorsitzender), Prof. Dr.-Ing. Harald Bolt,

Prof. Dr. Sebastian M. Schmidt

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[NMR] Research Assistant/Staff Scientist Position in DNP solid state NMR at the Weizmann Institute of Science, Israel #DNPNMR

A research assistant/staff scientist position is available in the group of Michal Leskes at the Department of Materials and Interfaces, Weizmann Institute of science, Israel.

The position involves: (i) Managing and running research projects within our research framework (described below and on our website) and (ii) taking a major part in guiding and training graduate students as well as managing our DNP-NMR lab.

Research in our group is focused on developing and using MAS-DNP and solid state NMR methods for materials science applications. A central topic is the development of endogenous DNP based on paramagnetic metal ion dopants in inorganic systems. 

The position is available initially for 5 years supported by ERC funding, with an option to transfer to a tenure track position (staff scientist), depending on the qualifications and performance in the first two years. 

Candidates should have a PhD in Chemistry/Physics/Engineering with proven hands-on experience in magnetic resonance. Postdoctoral experience or equivalent is an advantage. Excellent communication skills in English and ability to work in a research team are required.

Our lab is equipped with a Bruker 400MHz MAS-DNP spectrometer with LT-MAS DNP probes, as well as a wide range of MAS and static solids NMR probes. In addition to our lab dedicated equipment, extensive NMR and EPR systems are available on campus as part of our research support facilities – these include 400, 500 and 800MHz NMR spectrometers equipped with MAS systems and X and Q band pulse and CW EPR systems. 

The Weizmann Institute is located in a small, affordable and friendly town, 25 minutes from Tel Aviv and 45 minutes from Jerusalem, and is one of Israel’s premier scientific institutions. It is a research centre where the official language is English, and which offers numerous facilities to international visitors.

For additional information and application please contact Dr. Michal Leskes by email at michal.leskes@weizamnn.ac.il.

Applications should include CV, list of publications and contact details of at least two references.

Further details and relevant publications can be found on our website: http://www.weizmann.ac.il/materials/Leskes/.

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Dr. Michal Leskes

Department of Materials and Interfaces

Weizmann Institute of Science

Rehovot 7610001

Israel

Office: +972-8-934-2588

NMR Lab: +972-8-934-2424

Mobile: +972-544224001

http://www.weizmann.ac.il/materials/Leskes/home

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