Category Archives: Hardware Development

Open-Source Automated Parahydrogen Hyperpolarizer for Molecular Imaging Using 13C Metabolic Contrast Agents

Coffey, Aaron M., Roman V. Shchepin, Milton L. Truong, Ken Wilkens, Wellington Pham, and Eduard Y. Chekmenev. “Open-Source Automated Parahydrogen Hyperpolarizer for Molecular Imaging Using 13 C Metabolic Contrast Agents.” Analytical Chemistry 88, no. 16 (August 16, 2016): 8279–88.

https://doi.org/10.1021/acs.analchem.6b02130.

An open-source hyperpolarizer producing 13C hyperpolarized contrast agents using parahydrogen induced polarization (PHIP) for biomedical and other applications is presented. This PHIP hyperpolarizer utilizes an Arduino microcontroller in conjunction with a readily modified graphical user interface written in the open-source processing software environment to completely control the PHIP hyperpolarization process including remotely triggering an NMR spectrometer for efficient production of payloads of hyperpolarized contrast agent and in situ quality assurance of the produced hyperpolarization. Key advantages of this hyperpolarizer include: (i) use of opensource software and hardware seamlessly allowing for replication and further improvement as well as readily customizable integration with other NMR spectrometers or MRI scanners (i.e., this is a multiplatform design), (ii) relatively low cost and robustness, and (iii) in situ detection capability and complete automation. The device performance is demonstrated by production of a dose (∼2−3 mL) of hyperpolarized 13C-succinate with %P13C ∼ 28% and 30 mM concentration and 13C-phospholactate at %P13C ∼ 15% and 25 mM concentration in aqueous medium. These contrast agents are used for ultrafast molecular imaging and spectroscopy at 4.7 and 0.0475 T. In particular, the conversion of hyperpolarized 13C-phospholactate to 13C-lactate in vivo is used here to demonstrate the feasibility of ultrafast multislice 13C MRI after tail vein injection of hyperpolarized 13C-phospholactate in mice.

Post-doctoral position at CEA-Saclay in NMR hardware development

From the Ampere Magnetic Resonance List

Post-doctoral position at CEA-Saclay in NMR hardware development

We are looking for post-doctoral candidates, to join an exciting project on the development of a new approach to increase sensitivity with NMR spectroscopy. The project aims at developing magic angle coil spinning (MACS) for high-resolution micro-detection of volume-limited biomedical substances, using Dynamic Nuclear Polarization (DNP) and is funded by the French National Science Foundation (ANR). The role of the post-doc associate will be to participate in the development of new hardware on high-field and ultra-high field spectrometers. This project is pursued in close collaboration with the University Pierre and Marie Curie and the group of Prof. Christian Bonhomme.

Post-doctoral candidates should have strong experience in electrical engineering and/or magnetic resonance hardware development (e.g. radio-frequency probes, antennas), or connected areas of experimental physics and engineering.

Funding is available for at least one year, while possibilities for up to 30 months are accessible. Salary will be commensurate with experience.

Our team (http://dsakellariou.free.fr) is part of the laboratory of structure and dynamics by magnetic resonance lab (http://iramis.cea.fr/sis2m/lsdrm/), at the Department of Material Science division of CEA (http://www.cea.fr/english-portal). The group offers a unique environment where the research activity on magnetic resonance methodology and instrumentation encompasses pulse sequence development for solid-state NMR and MRI. The CEA is located 20 km from the heart of Paris, at the center of an extremely dynamic scientific cluster (http://www.epps.fr/en/a-global-cluster/).

Interested candidates should send their full CV to Dimitrios Sakellariou (Dimitrios.Sakellariou@cea.fr) and provide three references in a cover letter.

D. Sakellariou

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