Category Archives: Solutions

OpenVnmrJ for ODNP Spectroscopy

Control single-board NMR spectrometers with OpenVnmrJ

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Related Product:  X-Band Microwave Source for ODNP

Overhauser DNP Spectroscopy

Overhauser enhanced Dynamic Nuclear Polarization (ODNP) spectroscopy in general requires a microwave source, an ODNP resonator and an NMR spectrometer. Low-field ODNP spectroscopy is typically performed at a magnetic field of 0.35 T, corresponding to an NMR frequency of ~15 MHz for protons. While many laboratories rely on home-built ODNP equipment, they often use a commercial (high-field) NMR spectrometer to record the NMR spectrum. However, these spectrometers come with significant overhead and are no cost-effective solutions to ODNP resulting in a large, unnecessary investments.

An ODNP Microwave Source with Integrated NMR Spectrometer

ODNP experiments performed at 0.35 T require an NMR spectrometer operating at 15 MHz to observe protons. A single-board NMR spectrometer such as the RadioProcessor Board (SpinCore Technologies, Inc., Gainesville, FL USA) is a cost-effective solution and sufficient for most ODNP experiments. This integrated NMR spectrometer is now available as an additional option for our Microwave Power Source (Bridge12 MPS).

OpenVnmrJ

OpenVnmrJ for ODNP

Many researchers that are interested in ODNP spectroscopy come out of the NMR community but are often unfamiliar with the additional microwave equipment. In collaboration with Open VnmrJ Solutions, the team at Bridge12 Technologies, Inc. has developed a variant of OpenVnmrJ that is tailored towards ODNP spectroscopy to lower the entry barrier.

OpenVnmrJ is the Open Source variant of the highly successful VnmrJ 4.2 acquisition and processing software that many Varian/Agilent NMR users are familiar with. It offers the benefits of a state-of-the-art NMR acquisition and processing software, while maintaining the required flexibility to control auxiliary equipment such as the microwave source. The specific version of OpenVnmrJ and its functions to operate a single-board NMR spectrometer are released as Open Source to make it available to entire research community. OpenVnmrJ is the Open Source version of VnmrJ version 4.2. In 2015, Agilent agreed to transfer the copyright of VnmrJ 4.2 to the University of Oregon. The software is available through the OpenVnmrJ project hosted on GitHub.

If you would like to receive more information on OpenVnmrJ and its support of single-board NMR spectrometers do no hesitate to contact us a info@bridge12.com.

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Terahertz Technology

Terahertz technology has  applications as diverse as communication and imaging. Building a custom system can be challenging. Bridge12 offers active and passive THz technology components to help you achieve your goal. We assist engineers and scientists who are looking to source one or more components for their custom-built system based on terahertz technology. Components we offer include:

Active Terahertz Components

  • Electron Guns
  • Gyrotrons
  • Travelling Wave Tubes

Passive Terahertz Components

  • Custom Designed Transmission Lines
  • Miter Bends
  • Directional Couplers
  • Corrugated Waveguides
  • THz Power Detectors
  • THz Attenuator
  • Universal Polarizers
  • Matching Optic Units

Auxilliary Components

  • Gyrotron Control Systems
  • Power Meters
  • Frequency Measuring Systems

DNP-NMR Spectroscopy

Low signal-to-noise ratios present a huge challenge in nuclear magnetic resonance (NMR) spectroscopy and cause long acquisition times. They can make even some experiments outright impractical because they would require an unrealistic amount of spectrometer time.

To solve this challenge, you can boost the NMR signal intensity with dynamic nuclear polarization (DNP-NMR). Suitable mostly for solid-state NMR experiments, the method uses terahertz waves to provide a boost in NMR signal intensities by several orders of magnitude; thus increasing the signal intensity and data acquisition rate in a NMR experiment dramatically.

Four different components are required for dynamic nuclear polarization: 1) A polarizing agents (typically a biradical), 2) A low-temperature NMR probe that allows irradiation of the sample with THz and RF power, 3) A transmission line that delivers the THz power from the source to the sample and 4) A THz source such as a gyrotron.

DNP-NMR Spectroscopy

Bridge12 offers the required instrumentation to upgrade your new or existing NMR spectrometers to perform dynamic nuclear polarization (DNP) experiments. This can be a smart alternative to off-the-shelf DNP-NMR solutions with the potential of huge cost savings. A typical dynamic nuclear polarization upgrade of your existing NMR spectrometer requires the following terahertz components:

  • A Gyrotron to generate the terahertz waves for dynamic nuclear polarization experiments
  • Transmission Line to guide the terahertz waves from the source to your sample
  • DNP-NMR probe to perform low-temperature NMR experiments

We are happy to discuss the different options for upgrading or retrofitting your NMR spectrometer – just contact us. If you’re not quite ready to talk to us, feel free to read some of the articles in the Learn section.

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If you have questions about our instrumentation or how we can help you, please contact us.