Microwave Source for X-Band ODNP Experiments

Microwave Source for ODNP-Enhanced NMR Spectroscopy

Download Data Sheet

Related Product: X-Band ODNP Probe

Overhauser DNP Spectroscopy

Bridge12 X-Band microwave source for ODNP experiments

Overhauser Dynamic Nuclear Polarization (ODNP) enhanced NMR spectroscopy at 9 GHz (0.35 T, 15 MHz 1H NMR frequency) is a powerful method for site-specific studies of the accessibility and translational dynamics of water molecules at or near bio-macromolecules, membrane proteins, or polymer/solvent interfaces [1]. Although the method has been around since the 1960s, it has just recently been successfully applied in structural biology and material science. The unique instrumentation requirements had previously limited the application of ODNP-enhanced NMR spectroscopy, specifically the lack of commercially available microwave sources and DNP probes that are compatible with existing EPR instrumentation.

Upgrade your existing EPR Spectrometer

Unlike high-field DNP-enhanced solid-state NMR experiments ODNP -enhanced NMR spectroscopy at 9 GHz does not require a large superconducting NMR magnet or a gyrotron as the microwave source. In fact, any commercially available or home-built X-band EPR spectrometer, often found in academic spectroscopy facilities, can be easily upgraded with ODNP capabilities.

A turn-key microwave source so you can focus on your research

The Bridge12 MPS 9 GHz is a compact, easy to use X-band microwave source for ODNP spectroscopy. The maximum output power of commercially available, state-of-the-art EPR spectrometer is typically limited to < 300 mW, which is insufficient to drive the ODNP effect into saturation. The Bridge12 MPS is a simple add-on for existing EPR spectrometers and can deliver up to 10 W of microwave power to the sample. The system features easy to use front panel operation, a concise design, and several failsafe features to protect your sample and your EPR instrumentation. You don’t have to be an expert in microwave technology to operate this system and can keep the focus on your research instead of troubleshooting home-built instrumentation. Simply set the correct microwave frequency and output power, enable the microwave output, and start recording ODNP-enhanced NMR spectra. For more advanced users the system features an optional external trigger to modulate the microwave power directly from the NMR console and a USB interface for deeper integration of the source into the target application.

The Bridge12 MPS Front Panel

Easy to operate user interface

The Bridge12 MPS features a simple and concise user interface. The front panel display is designed to show only the important values in an easy to read font size, even from a distance.

A modular platform with many additional options

The Bridge12 MPS has a modular design and can be upgraded with different additional features. In addition to the basic functionalities, the source can be configured for short pulse operation (< 2 ns) for users that are interested in pulsed ODNP experiments. To critically couple the microwave resonator without the use of an existing EPR spectrometer, a tuning/ matching circuit can be added to the system to display the cavity tuning in real time. This will also allow for constant monitoring of the reflected microwave power during the ODNP experiment to prevent excessive sample heating. Bridge12 offers a connection kit for seamlessly integration of the ODNP microwave source and probe into existing EPR instrumentation. This allows to simply switch back and forth between EPR and DNP operation. The kit includes a waveguide switch that can be operated manually or automatically to ensure the safety of your EPR equipment. The Bridge12 MPS for ODNP-enhanced NMR spectroscopy is also available for experiments at K (24 GHz) and Q (35 GHz) band.

Technical Specifications

  • Frequency Range: 9.3 – 10.5 GHz (also available for Q and K-band spectrometers)
  • Maximum Output power: 5 or 10 W (cw). Continuous attenuation from -10 dBm to 37 (40) dBm in steps of 0.5 dB
  • Operation: Front Panel operation. Digital interface (USB) for remote operation (optional)
  • TTL pulse modulation (optional): 100 ns minimum pulse length, 50 % minimum duty cycle (shorter pulses available).
  • Temperature monitor and safety switch to prevent overheating of the amplifier.
  • System size (W x H x D): 12 x 7 x 14 (inch), 30.5 x 17.8 x 35.6 (cm)
  • System weight: 3.3 lbs (1.5 kg)
  • Input power: 110 – 220 V (50/60 Hz)

[1] Franck, J.M., et al., Quantitative cw Overhauser effect dynamic nuclear polarization for the analysis of local water dynamics. Prog. Nucl. Magn. Reson. Spectrosc., 2013. 74(0): p. 33-56.

Download Data Sheet

Have a question?

If you have questions about our instrumentation or how we can help you, please contact us.